Evidence map›Paper›PMID 35447889›Full record

ArticleNon-coding RNA2022

Patterns of Differentially Expressed circRNAs in Human Thymocytes.

Pilar López-Nieva, Pablo Fernández-Navarro, María Ángeles Cobos-Fernández, Iria González-Vasconcellos, Raúl Sánchez Pérez, Ángel Aroca, José Fernández-Piqueras, Javier Santos

Open access · goldAbstract read
In one paragraph

Article in Non-coding RNA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Pilar López-NievaGenome Dynamics and Function Program, Genome Decoding Department, Severo Ochoa Molecular Biology Center (CBMSO), CSIC-Madrid Autonomous University, 28049 Madrid, Spain.ORCID 0000-0001-6369-2444
Pablo Fernández-NavarroCancer and Environmental Epidemiology Unit, National Center for Epidemiology, Institute of Health Carlos III, 28029 Madrid, Spain.ORCID 0000-0001-9427-2581
María Ángeles Cobos-FernándezGenome Dynamics and Function Program, Genome Decoding Department, Severo Ochoa Molecular Biology Center (CBMSO), CSIC-Madrid Autonomous University, 28049 Madrid, Spain.
Iria González-VasconcellosGenome Dynamics and Function Program, Genome Decoding Department, Severo Ochoa Molecular Biology Center (CBMSO), CSIC-Madrid Autonomous University, 28049 Madrid, Spain.ORCID 0000-0002-4688-5508
Raúl Sánchez PérezDepartment of Congenital Cardiac Surgery, Hospital Universitario La Paz, 28046 Madrid, Spain.
Ángel ArocaDepartment of Congenital Cardiac Surgery, Hospital Universitario La Paz, 28046 Madrid, Spain.
José Fernández-PiquerasGenome Dynamics and Function Program, Genome Decoding Department, Severo Ochoa Molecular Biology Center (CBMSO), CSIC-Madrid Autonomous University, 28049 Madrid, Spain.ORCID 0000-0003-4520-6785
Javier SantosGenome Dynamics and Function Program, Genome Decoding Department, Severo Ochoa Molecular Biology Center (CBMSO), CSIC-Madrid Autonomous University, 28049 Madrid, Spain.ORCID 0000-0002-4168-6251
Hospital Universitario Fundación Jiménez Díaz · ESHospital Universitario La Paz · ESInstituto de Salud Carlos III · ES

Funding

Asociación Española Contra el Cáncer AECC, 2018; PROYE18054PIRIAutonomous Community of Madrid, Spain B2017/BMD-3778; LINFOMAS-CMRamón Areces Fundation CIVP19S7917Spanish Ministry of Science, Innovation and Universities RTI2018-093330-B-I00; MCIU/FEDER, EUSpanish Ministry of Science, Innovation and Universities Juan de la Cierva Grant IJCI-2016-29155
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are suggested to play a discriminative role between some stages of thymocyte differentiation. However, differential aspects of the stage of mature single-positive thymocytes remain to be explored. The purpose of this study is to investigate the differential expression pattern of circRNAs in three different development stages of human thymocytes, including mature single-positive cells, and perform predictions in silico regarding the ability of specific circRNAs when controlling the expression of genes involved in thymocyte differentiation. We isolate human thymocytes at three different stages of intrathymic differentiation and determine the expression of circRNAs and mRNA by RNASeq. We show that the differential expression pattern of 50 specific circRNAs serves to discriminate between the three human thymocyte populations. Interestingly, the downregulation of

Indexed as

circRNA–miRNA–mRNA controlling networkscircRNAshuman thymocytes

Identifiers

PMID35447889
PMCPMC9030292
OpenAlexW4221003834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.