Evidence map›Paper›PMID 35447886›Full record

ReviewNon-coding RNA2022

Current Status of Epitranscriptomic Marks Affecting lncRNA Structures and Functions.

Henry E Miller, Mirolyuba Ilieva, Alexander J R Bishop, Shizuka Uchida

Open access · goldAbstract readReview
In one paragraph

Review in Non-coding RNA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Benchmarking RNA Editing Detection Tools.Biotech (Basel (Switzerland)) · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Henry E MillerDepartment of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0003-3756-3918
Mirolyuba IlievaCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen SV, Denmark.
Alexander J R BishopDepartment of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0002-5742-4387
Shizuka UchidaCenter for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen SV, Denmark.ORCID 0000-0003-4787-8067
Aalborg University · DKThe University of Texas Health Science Center at San Antonio · US

Funding

Dysregulated transcription processes in Ewing sarcoma:R01CA241554 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BISHOP, ALEXANDER JAMES · 2020 to 2025
$2.3M
The dynamics and impact of R-loops in epigenetic stability and agingF31AG072902 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MILLER, HENRY · 2021 to 2022
$41k
Cancer Research UK RT6187Greehey Family Foundation Greehey graduate fellowshipNCI NIH HHS R01 CA241554NIA NIH HHS F31 AG072902NIH HHS 1R01CA241554NIH HHS F31AG072902Novo Nordisk Foundation NNF18OC0033438
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) belong to a class of non-protein-coding RNAs with their lengths longer than 200 nucleotides. Most of the mammalian genome is transcribed as RNA, yet only a small percent of the transcribed RNA corresponds to exons of protein-coding genes. Thus, the number of lncRNAs is predicted to be several times higher than that of protein-coding genes. Because of sheer number of lncRNAs, it is often difficult to elucidate the functions of all lncRNAs, especially those arising from their relationship to their binding partners, such as DNA, RNA, and proteins. Due to their binding to other macromolecules, it has become evident that the structures of lncRNAs influence their functions. In this regard, the recent development of epitranscriptomics (the field of study to investigate RNA modifications) has become important to further elucidate the structures and functions of lncRNAs. In this review, the current status of lncRNA structures and functions influenced by epitranscriptomic marks is discussed.

Indexed as

epitranscriptomicsgene expressionlncRNARNA-seq

Identifiers

PMID35447886
PMCPMC9025719
OpenAlexW4220990920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.