Evidence map›Paper›PMID 35447423›Full record

ArticleEnvironment international2022

Identifying environmental factors that influence immune response to SARS-CoV-2: Systematic evidence map protocol.

Swati D G Rayasam, Max T Aung, Courtney Cooper, Carol Kwiatkowski, Dori R Germolec, Andrew A Rooney, Vickie R Walker, Chanese Forte, Tracey J Woodruff, Nicholas Chartres

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Immuno-modulatory Effects of InactivatedAdvanced biomedical research · 2023
    Article
  5. Cumulative effects of air pollution and climate drivers on COVID-19 multiwaves in Bucharest, Romania.Process safety and environmental protection : transactions of the Institution of Chemical Engineers, Part B · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Swati D G RayasamProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, Box 0132, 490 Illinois Street, Floor 10, San Francisco, CA 94143, United States. Electronic address: swati.rayasam@ucsf.edu.
Max T AungProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, Box 0132, 490 Illinois Street, Floor 10, San Francisco, CA 94143, United States. Electronic address: maxaung@usc.edu.
Courtney CooperProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, Box 0132, 490 Illinois Street, Floor 10, San Francisco, CA 94143, United States. Electronic address: courtney.cooper@ucsf.edu.
Carol KwiatkowskiDepartment of Biological Sciences, North Carolina State University, 112 Derieux Place, Room 3510 Thomas Hall, CB 7614, Raleigh, NC 27695, United States.
Dori R GermolecDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, 530 Davis Drive, Research Triangle Park, NC, 27560, United States. Electronic address: dori.germolec@nih.gov.
Andrew A RooneyDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, 530 Davis Drive, Research Triangle Park, NC, 27560, United States. Electronic address: andrew.rooney@nih.gov.
Vickie R WalkerDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, 530 Davis Drive, Research Triangle Park, NC, 27560, United States. Electronic address: vickie.walker@nih.gov.
Chanese ForteProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, Box 0132, 490 Illinois Street, Floor 10, San Francisco, CA 94143, United States. Electronic address: chanese.forte@ucsf.edu.
Tracey J WoodruffProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, Box 0132, 490 Illinois Street, Floor 10, San Francisco, CA 94143, United States. Electronic address: tracey.woodruff@ucsf.edu.
Nicholas ChartresProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, Box 0132, 490 Illinois Street, Floor 10, San Francisco, CA 94143, United States. Electronic address: nicholas.chartres@ucsf.edu.

Funding

Scientific Cyberinfrastructure Research ProgramZIAES103385 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, VICKIE · 2022 to 2025
$17.4M
Consumer Products and Therapeutics Research ProgramZIAES103379 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, KYLA · 2022 to 2025
$9.9M
Research Initiatives on COVID-19 in the Division of Translational ToxicologyZIAES103367 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI GERMOLEC, DORI R · 2021 to 2025
$4.5M
6 · The paper itself

Abstract

backgroundWidespread environmental contamination can directly interact with human immune system functions. Environmental effects on the immune system may influence human susceptibility to respiratory infections as well as the severity of infectious diseases, such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Furthermore, the efficacy of vaccines to respiratory diseases may be impacted by environmental exposures through immune perturbations. Given the quick pace of research about COVID-19 and associated risk factors, it is critical to identify and curate the streams of evidence quickly and effectively.

objectiveWe developed this systematic evidence map protocol to identify and organize existing human and animal literature on high-priority environmental chemical classes (Per- and polyfluoroalkyl substances, pesticides, phthalates, quaternary ammonium compounds, and air pollutants) and their potential to influence three key outcomes: (1) susceptibility to respiratory infection, including SARS-CoV-2 (2) severity of the resultant disease progression, and (3) impact on vaccine efficacy. The result of this project will be an online, interactive database which will show what evidence is currently available between involuntary exposures to select environmental chemicals and immune health effects, data gaps that require further research, and data rich areas that may support further analysis. SEARCH AND STUDY ELIGIBILITY: We will search PubMed for epidemiological or toxicological literature on select toxicants from each of the chemical classes and each of the three outcomes listed above. STUDY APPRAISAL AND SYNTHESIS OF

methodsFor each study, two independent reviewers will conduct title and abstract screening as well as full text review for data extraction of study characteristics. Study quality will not be evaluated in this evidence mapping. The main findings from the systematic evidence map will be visualized using a publicly available and interactive database hosted on Tableau Public.

Indexed as

COVID-19SARS-CoV-2AnimalsAntineoplastic Combined Chemotherapy ProtocolsCisplatinDoxorubicinEnvironmental ExposureImmunityMitomycinCisplatinDoxorubicinMitomycinAir pollutantsCOVID-19Per- and polyfluoroalkyl substances (PFAS)PesticidesPhthalatesQuaternary Ammonium Compounds (QACs)Respiratory disease severityRespiratory virus susceptibilitySARS-CoV-2Systematic evidence mapVaccine efficacy

Identifiers

PMID35447423
PMCPMC8989740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.