Evidence map›Paper›PMID 35446993›Full record

ArticleJournal of clinical laboratory analysis2022

Exosomal circular RNA hsa_circ_0006220, and hsa_circ_0001666 as biomarkers in the diagnosis of pancreatic cancer.

Lu Hong, Liu Xu, Lufei Jin, Kaiwei Xu, Weiwei Tang, Yuchao Zhu, Xuedan Qiu, Jianhua Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  16. Progress of Exosomal LncRNAs in Pancreatic Cancer.International journal of molecular sciences · 2024
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  18. Article
  19. Exosomes: Emerging Insights into the Progression of Pancreatic Cancer.International journal of biological sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lu HongDepartment of Radiology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China.ORCID https://orcid.org/0000-0001-5518-022X
Liu XuDepartment of Radiology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China.
Lufei JinDepartment of Radiology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China.
Kaiwei XuDepartment of Radiology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China.
Weiwei TangDepartment of Radiology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China.
Yuchao ZhuDepartment of Radiology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China.
Xuedan QiuNingbo Medical Center Lihuili Eastern Hospital, Ningbo, China.
Jianhua WangDepartment of Radiology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China.
Ningbo University · CNNingbo Medical Center Lihuili Hospital · CN

Funding

Commonweal Foundation of Ningbo city 20211JCGY020358Major Medical and Health Science and Technology Program of the National Health Commission WKJ-ZJ-1912Natural Science Foundation of Nation 82172004Natural Science Foundation of Ningbo 2019A610206Natural Science Foundation of Ningbo 2021J254Natural Science Foundation of Zhejiang Province Y20H180008
6 · The paper itself

Abstract

backgroundPancreatic cancer is a highly malignant tumor of the digestive system.

objectiveExosomal circular RNA can be used as a biomarker for the early diagnosis of pancreatic cancer.

methodsThe expression of various differentially expressed circRNAs in pancreatic cancer tissues was analyzed by gene chip, exosome expression was verified by electron microscopy and Western blotting, and the expression of exosomal circRNA in pancreatic cancer cells, tissues, and plasma were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).

resultsCompared with healthy controls, hsa_circ_0006220 and hsa_circ_0001666 were highly expressed in exosomes in the plasma of pancreatic cancer patients. The AUC values were 0.7817 for hsa_circ_0006220, 0.8062 for hsa_circ_0001666, and 0.884 for the combined diagnosis. In addition, clinicopathological features revealed that the expression of hsa_circ_0006220 in plasma exosomes from pancreatic cancer patients was associated with CA19-9 levels (p = 0.0001) and lymph node metastasis (p = 0.0005). The expression of hsa_circ_0001666 was correlated with both tumor size (p = 0.0157) and CA19-9 level (p = 0.0001).

conclusionsThe high expression of exosomal hsa_circ_0001666 and hsa_circ_0006220 suggests that these can be used as new biomarkers for the diagnosis and treatment of pancreatic cancer.

Indexed as

Pancreatic NeoplasmsRNA, CircularBiomarkers, TumorCA-19-9 AntigenEarly Detection of CancerHumansRNABiomarkers, TumorCA-19-9 AntigenRNARNA, CircularbiomarkerCircRNAexosomepancreatic cancer

Identifiers

PMID35446993
PMCPMC9169197
OpenAlexW4224219117

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.