ArticlePLoS genetics2022
A locus conferring tolerance to Theileria infection in African cattle.
Article in PLoS genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 28 citations in OpenAlex.
- Harnessing adaptive alleles in native animals for sustainable intensification of livestock.Animal frontiers : the review magazine of animal agriculture · 2026Article
- Integrative Genomics Identifies Candidate Genes Underlying Trypanotolerance in Hybrid African Cattle.Evolutionary applications · 2026Article
- Distinct adaptation and ancestral retention signals in African and European indigenous cattle genomes.Communications biology · 2026Article
- Canine Ticks, Tick-Borne Pathogens and Associated Risk Factors in Nigeria.Pathogens (Basel, Switzerland) · 2025Article
- Genomic and health characteristics of crossbred dairy cattle in central Uganda.Frontiers in genetics · 2025Article
- Genome-wide local ancestry and the functional consequences of admixture in African and European cattle populations.Heredity · 2025Article
- Genetic estimates and genome-wide association studies of antibody response in Tanzanian dairy cattle.Frontiers in genetics · 2025Article
- Selection for Resilience in Livestock Production Systems.International journal of molecular sciences · 2024Review
- Insights into trait-association of selection signatures and adaptive eQTL in indigenous African cattle.BMC genomics · 2024Article
- Continent-wide genomic analysis of the African buffalo (Syncerus caffer).Communications biology · 2024Article
- Structural variant landscapes reveal convergent signatures of evolution in sheep and goats.Genome biology · 2024Article
- Comparative transcriptional analysis identifies genes associated with the attenuation of Theileria parva infected cells after long-term in vitro culture.Scientific reports · 2024Article
- Characterization of heterozygosity-rich regions in Italian and worldwide goat breeds.Scientific reports · 2024Article
- Profiling the immune epigenome across global cattle breeds.Genome biology · 2023Article
- Meta-analysis of heritability estimates and genome-wide association for tick-borne haemoparasites in African cattle.Frontiers in genetics · 2023Article
- Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle.Genomics · 2022Article
- Clinical Evaluation of Corridor Disease inFrontiers in veterinary science · 2021Article
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Authors and funding
25 authors at 3 institutions in 2 countries.
Funding
Abstract
East Coast fever, a tick-borne cattle disease caused by the Theileria parva parasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a cohort of Bos indicus (Boran) cattle demonstrating heritable tolerance to infection with T. parva (h2 = 0.65, s.e. 0.57). Through a linkage analysis we identify a 6 Mb genomic region on bovine chromosome 15 that is significantly associated with survival outcome following T. parva exposure. Testing this locus in an independent cohort of animals replicates this association with survival following T. parva infection. A stop gained variant in a paralogue of the FAF1 gene in this region was found to be highly associated with survival across both related and unrelated animals, with only one of the 20 homozygote carriers (T/T) of this change succumbing to the disease in contrast to 44 out of 97 animals homozygote for the reference allele (C/C). Consequently, we present a genetic locus linked to tolerance of one of Africa's most important cattle diseases, raising the promise of marker-assisted selection for cattle that are less susceptible to infection by T. parva.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.