Evidence map›Paper›PMID 35446725›Full record

SynthesisHuman vaccines & immunotherapeutics2022

Burden of vaccine-preventable diseases among at-risk adult populations in the US.

Irina Kolobova, Mawuli Kwame Nyaku, Anna Karakusevic, Daisy Bridge, Iain Fotheringham, Megan O'Brien

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Human vaccines & immunotherapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  12. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Irina KolobovaCenter for Observational and Real World Evidence, Merck & Co., Inc., Kenilworth, New Jersey, USA.
Mawuli Kwame NyakuCenter for Observational and Real World Evidence, Merck & Co., Inc., Kenilworth, New Jersey, USA.
Anna KarakusevicAdelphi Values PROVE, Bollington, UK.
Daisy BridgeAdelphi Values PROVE, Bollington, UK.
Iain FotheringhamAdelphi Values PROVE, Bollington, UK.
Megan O'BrienCenter for Observational and Real World Evidence, Merck & Co., Inc., Kenilworth, New Jersey, USA.
Adelphi Group (United Kingdom) · GBMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Life-course immunization holds significant benefit for population health by reducing the burden of vaccine-preventable diseases (VPD) through vaccinating individuals at different stages and circumstances in life. The study aimed to determine the epidemiologic, clinical, economic, and societal burden of VPDs among at-risk adult subpopulations in the United States. A systematic literature review was conducted for articles published between January 2010 and June 2020, which identified 72 publications. There was heterogeneity in available epidemiology data, with the prevalence of VPDs ranging from 1.1% to 68.7%. Where the disease burden was described, outcomes were typically worse among high-risk subpopulations than in the general population. Several VPDs, including herpes zoster, meningococcal, and pneumococcal infections were associated with increased costs. This review suggests that subpopulations may not frequently interact with the healthcare system, or their risk factors may not be recognized by healthcare providers, and therefore individuals may not be appropriately targeted for vaccination.

Indexed as

Herpes ZosterPneumococcal InfectionsVaccine-Preventable DiseasesAdultHumansRisk FactorsUnited StatesVaccinationat-risk populationdisease burdenlife-course immunizationpopulation healthpublic healthVaccine-Preventable diseases

Identifiers

PMID35446725
PMCPMC9225203
OpenAlexW4224241637

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.