SynthesisJournal of geriatric psychiatry and neurology2023
Apathy as a Predictor for Conversion From Mild Cognitive Impairment to Dementia: A Systematic Review and Meta-Analysis of Longitudinal Studies.
Synthesis in Journal of geriatric psychiatry and neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Unawareness of deficits in mild cognitive impairment: a systematic review of its role in progression to Alzheimer's disease.BMC neurology · 2026Pooled it
- The Associations Between Neuropsychiatric Symptoms and Cognition in People with Dementia: A Systematic Review and Meta-Analysis.Neuropsychology review · 2024Pooled it
- Apathy in dementia with Lewy bodies: Frequency, correlates, and impact on patient and caregiver experiences.Parkinsonism & related disorders · 2026Article
- Neuropsychiatric symptoms and dementia development: a 15-year population-based study.The journal of prevention of Alzheimer's disease · 2026Article
- Glial Cells in Behavioral and Psychological Symptoms of Alzheimer's Disease.International journal of molecular sciences · 2026Review
- Suppression of neuronal eEF2K alleviates cognitive deficits and apathy-like behavior in APP/PS1 AD model mice.Research square · 2026Article
- Apathy, depression, and dementia risk in older adults: A global collaborative study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Apathy Is Associated with Slower Gait and Subjective Cognitive Complaints in a South Indian Community-Dwelling Cohort.Brain sciences · 2025Article
- Conversion to Mild Cognitive Impairment and Alzheimer's Disease Dementia Related to Apathy,Journal of geriatric psychiatry and neurology · 2025Article
- Probiotic Supplementation Improves the Clinical Measures of Cognition in Patients With Mild Cognitive Impairment.Cureus · 2025Review
- Advances in the study of apathy related to cerebral small vessel disease.Frontiers in neurology · 2025Review
- Behavioral and psychological symptoms and brain volumes in community-dwelling older persons from the Nakayama Study.Scientific reports · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- An Update on Apathy in Alzheimer's Disease.Geriatrics (Basel, Switzerland) · 2023Review
- Validation study of the apathy motivation index in French adults.Frontiers in psychology · 2023Article
- BPSDiary study protocol: a multi-center randomized controlled trial to compare the efficacy of a BPSD diary vs. standard care in reducing caregiver's burden.Frontiers in dementia · 2023Article
- Cutoff scores for the "Interest game", an application for the assessment of diminished interest in neurocognitive disorders.Frontiers in psychiatry · 2023Article
- The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and biological research.Translational psychiatry · 2022Review
- Apathy andAlzheimer's & dementia (New York, N. Y.) · 2022Article
- Procrastination as a marker of cognitive decline: Evidence from longitudinal transitions in the older adult population.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApathy is one of the most prevalent neurobehavioral manifestations in mild cognitive impairment (MCI) and is included among the behavioral and psychological symptoms of dementia (BPSD). Studies suggest that the presence of apathy could be associated with increased dementia risk. The role of apathy in conversion from MCI to dementia, and whether apathy could be a relevant predictor for dementia progression, are still matters of investigation.
aimTo study the relationship between apathy and progression to dementia in individuals with MCI.
methodsA systematic literature search in Medline, Embase, Cochrane Library, Epistemonikos, PsychINFO, and CINAHL was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search included longitudinal studies reporting on the association between apathy and dementia.
resultsThe main outcome was pooled unadjusted hazard ratios (HR) of apathy in dementia conversion and included 11 studies with 9504 individuals. There was a significant association between apathy and dementia conversion, HR = 1.54; 95% CI, 1.29, 1.84. Subgroup analysis showed a significant association between apathy and progression to AD.
conclusionApathy was associated with an increased risk of conversion to AD and all-cause dementia in patients with MCI. The role of apathy as a marker for incident dementia needs to be investigated in large, high-quality studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.