ArticleProceedings of the National Academy of Sciences of the United States of America2022
Propulsive colonic contractions are mediated by inhibition-driven poststimulus responses that originate in interstitial cells of Cajal.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Central control of gastrointestinal functions in health and disease.Physiological reviews · 2026Review
- Disruption of gastrointestinal PDGFRαAmerican journal of physiology. Gastrointestinal and liver physiology · 2026Article
- Clinical efficacy evaluation of ultrasound-guided tuina therapy for pediatric intussusception.Frontiers in medicine · 2026Article
- Modeling based insights into mechanical dysfunction in esophageal motility disorders.PLoS computational biology · 2025Article
- Neuronal regulation of myenteric interstitial cells of Cajal (ICC-MY) in the proximal colon.Cell calcium · 2025Article
- Kaempferol Inhibits Colonic Contractions via L‑Type Voltage-Dependent Calcium Channels in Murine Smooth Muscle Cells.ACS omega · 2025Article
- Diffuse pacemaker mechanism with distinctive organization drives pulsation in the octocoralProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Enteric glial S100B controls rhythmic colonic functions by regulating excitability and specificity in gut motor neurocircuits.The Journal of physiology · 2025Article
- TMEM16A in gastrointestinal and vascular smooth muscle contractility.The Journal of physiology · 2025Review
- ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions.Scientific reports · 2025Article
- Synaptic cell adhesion moleculeeLife · 2025Article
- Unique properties of proximal and distal colon reflect distinct motor functions.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Novel imaging approach for simultaneous tracking of cell dynamics in distinct tissue layers reveals cells involved in colonic peristalsis.Frontiers in imaging (Lausanne, Switzerland) · 2025Article
- Ca²⁺ signaling in myenteric interstitial cells of Cajal (ICC-MY) and their role as conditional pacemakers in the colon.Cell calcium · 2025Article
- Integrated responses of the SIP syncytium generate a major motility pattern in the colon.The Journal of physiology · 2024Article
- Interstitial cells of the sip syncytium regulate basal membrane potential in murine gastric corpus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Characterization of neuromuscular transmission and projections of muscle motor neurons in the rat stomach.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- CaPhysiological reviews · 2024Review
- An Optogenetics-based Approach to Regulate Colonic Contractions by Modulating the Activity of the Interstitial Cells of Cajal in Mice.Journal of neurogastroenterology and motility · 2023Article
- Arctiin alleviates functional constipation by enhancing intestinal motility in mice.Experimental and therapeutic medicine · 2023Article
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
The peristaltic reflex is a fundamental behavior of the gastrointestinal (GI) tract in which mucosal stimulation activates propulsive contractions. The reflex occurs by stimulation of intrinsic primary afferent neurons with cell bodies in the myenteric plexus and projections to the lamina propria, distribution of information by interneurons, and activation of muscle motor neurons. The current concept is that excitatory cholinergic motor neurons are activated proximal to and inhibitory neurons are activated distal to the stimulus site. We found that atropine reduced, but did not block, colonic migrating motor complexes (CMMCs) in mouse, monkey, and human colons, suggesting a mechanism other than one activated by cholinergic neurons is involved in the generation/propagation of CMMCs. CMMCs were activated after a period of nerve stimulation in colons of each species, suggesting that the propulsive contractions of CMMCs may be due to the poststimulus excitation that follows inhibitory neural responses. Blocking nitrergic neurotransmission inhibited poststimulus excitation in muscle strips and blocked CMMCs in intact colons. Our data demonstrate that poststimulus excitation is due to increased Ca2+ transients in colonic interstitial cells of Cajal (ICC) following cessation of nitrergic, cyclic guanosine monophosphate (cGMP)-dependent inhibitory responses. The increase in Ca2+ transients after nitrergic responses activates a Ca2+-activated Cl− conductance, encoded by Ano1, in ICC. Antagonists of ANO1 channels inhibit poststimulus depolarizations in colonic muscles and CMMCs in intact colons. The poststimulus excitatory responses in ICC are linked to cGMP-inhibited cyclic adenosine monophosphate (cAMP) phosphodiesterase 3a and cAMP-dependent effects. These data suggest alternative mechanisms for generation and propagation of CMMCs in the colon.
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