Evidence map›Paper›PMID 35446130›Full record

ArticleJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics2022

Gene Delivery of a Caspase Activation and Recruitment Domain Improves Retinal Pigment Epithelial Function and Modulates Inflammation in a Mouse Model with Features of Dry Age-Related Macular Degeneration.

Mayur Choudhary, Cristhian J Ildefonso, Alfred S Lewin, Goldis Malek

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mayur ChoudharyAlbert Eye Research Institute, Department of Ophthalmology, Duke Eye Center, Duke University School of Medicine, Durham, North Carolina, USA.
Cristhian J IldefonsoDepartment of Ophthalmology, University of Florida College of Medicine, Gainesville, Florida, USA.
Alfred S LewinDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA.
Goldis MalekAlbert Eye Research Institute, Department of Ophthalmology, Duke Eye Center, Duke University School of Medicine, Durham, North Carolina, USA.
Duke University · USUniversity of Florida · US

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Vadim Y Arshavsky · 1985 to 2026
$19.3M
Novel signaling pathways regulated by the liver x receptor in age-related macular degenerationR01EY027802 · NEI · DUKE UNIVERSITY · PI MALEK, GOLDIS · 2018 to 2021
$1.9M
Nuclear receptor driven mechanisms in aging and AMDR01EY032751 · NEI · DUKE UNIVERSITY · PI MALEK, GOLDIS · 2021 to 2024
$1.8M
Regulation of inflammation and lipid homeostasis by the aryl hydrocarbon receptor in age-related macular degenerationR01EY028160 · NEI · DUKE UNIVERSITY · PI MALEK, GOLDIS · 2018 to 2021
$1.8M
NEI NIH HHS P30 EY005722NEI NIH HHS R01 EY027802NEI NIH HHS R01 EY028160NEI NIH HHS R01 EY032751
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Macular DegenerationRetinal PigmentsAnimalsCaspase Activation and Recruitment DomainDisease Models, AnimalGenetic TherapyInflammationMiceRetinal Pigment EpitheliumRetinal PigmentsAAV therapyage-related macular degenerationinflammationNLRP3 inflammasomepreventionretinal function

Identifiers

PMID35446130
PMCPMC9242724
OpenAlexW4224211865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.