ArticleThe journal of physical chemistry letters2022
The First Stages of Nanomicelle Formation Captured in the Sevoflurane Trimer.
Article in The journal of physical chemistry letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Space filling shapes the interaction networks in mixed pyrrole-benzene trimers and tetramers.Communications chemistry · 2026Article
- Rotational Spectroscopy Pinpoints the Tetrahydrate as the Onset of Water Self-Aggregation in Sevoflurane Hydration.The journal of physical chemistry letters · 2025Article
- Microhydration Dynamics in Molecular Photoswitches: Equilibrium State Reconfiguration in Imine-Based Architectures.Angewandte Chemie (International ed. in English) · 2025Article
- Alcohol Self-Aggregation: the Preferred Configurations of the Ethanol Trimer.Angewandte Chemie (International ed. in English) · 2025Article
- Article
- Hydrogen Bonding in the Dimer and Monohydrate of 2-Adamantanol: A Test Case for Dispersion-Corrected Density Functional Methods.Molecules (Basel, Switzerland) · 2022Article
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Authors and funding
5 authors.
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Abstract
Self-aggregation of sevoflurane, an inhalable, fluorinated anesthetic, provides a challenge for current state-of-the-art high-resolution techniques due to its large mass and the variety of possible hydrogen bonds between monomers. Here we present the observation of sevoflurane trimer by chirped-pulse Fourier transform microwave spectroscopy, identified through the interplay of experimental and computational methods. The trimer (>600 Da), one of the largest molecular aggregates observed through rotational spectroscopy, does not resemble the binding (C-H···O) motif of the already characterized sevoflurane dimer, instead adapting a new binding configuration created predominantly from 17 CH···F hydrogen bonds that resembles a nanomicellar arrangement. The observation of such a heavy aggregate highlights the potential of rotational spectroscopy to study larger biochemical systems in the limit of spectroscopic congestion but also showcases the challenges ahead as the mass of the system increases.
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