Evidence map›Paper›PMID 35446001›Full record

ReviewAnnals of biomedical engineering2022

Alginate-Based Hydrogels and Tubes, as Biological Macromolecule-Based Platforms for Peripheral Nerve Tissue Engineering: A Review.

Walid Kamal Abdelbasset, Saade Abdalkareem Jasim, Satish Kumar Sharma, Ria Margiana, Dmitry Olegovich Bokov, Maithm A Obaid, Baydaa Abed Hussein, Holya A Lafta, Sara Firas Jasim, Yasser Fakri Mustafa

Abstract readReview
PubMed Publisher
In one paragraph

Review in Annals of biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 6 countries.

Walid Kamal AbdelbassetDepartment of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, P.O. Box. 173, Al-Kharj, 11942, Saudi Arabia. walidkamal.wr@gmail.com.ORCID http://orcid.org/0000-0003-4703-661X
Saade Abdalkareem JasimMedical Laboratory Techniques Department, Al-maarif University College, Al-anbar-Ramadi, Iraq.
Satish Kumar SharmaPharmacology Department, Glocal School of Pharmacy, The Glocal University, Saharanpur, India.
Ria MargianaDepartment of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. ria.margiana@ui.ac.id.
Dmitry Olegovich BokovInstitute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, Russian Federation, 119991.
Maithm A ObaidCollege of Pharmacy, National University of Science and Technology, Thi Qar, Iraq.
Baydaa Abed HusseinAl-Manara College for Medical Sciences, Misan, Iraq.
Holya A LaftaAl-Nisour University College, Baghdad, Iraq.
Sara Firas JasimDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.
Yasser Fakri MustafaDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.
University of Mosul · IQAl-Nisour University College · IQGlocal University · INPrince Sattam Bin Abdulaziz University · SASechenov University · RUThi Qar University · IQUniversity of Indonesia · ID

Funding

Princess Nourah bint Abdulrahman University Researchers Supporting PNURSP2022R145Taif University Researchers Supporting TURSP-2020/117
6 · The paper itself

Abstract

Unlike the central nervous system, the peripheral nervous system (PNS) has an inherent capacity to regenerate following injury. However, in the case of large nerve defects where end-to-end cooptation of two nerve stumps is not tension-free, autologous nerve grafting is often utilized to bridge the nerve gaps. To address the challenges associated with autologous nerve grafting, neural guidance channels (NGCs) have been successfully translated into clinic. Furthermore, hydrogel-based drug delivery systems have been extensively studied for the repair of PNS injuries. There are numerous biomaterial options for the production of NGCs and hydrogels. Among different candidates, alginate has shown promising results in PNS tissue engineering. Alginate is a naturally occurring polysaccharide which is biocompatible, non-toxic, non-immunogenic, and possesses modifiable properties. In the current review, applications, challenges, and future perspectives of alginate-based NGCs and hydrogels in the repair of PNS injuries will be discussed.

Indexed as

HydrogelsTissue EngineeringAlginatesNerve RegenerationPeripheral NervesTissue ScaffoldsAlginatesHydrogelsAlginateHydrogelNeural guidance channelsPeripheral nervous systemTissue regeneration

Identifiers

PMID35446001
OpenAlexW4224230940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.