ArticleAnnals of intensive care2022
A randomised controlled trial of non-invasive ventilation compared with extracorporeal carbon dioxide removal for acute hypercapnic exacerbations of chronic obstructive pulmonary disease.
Article in Annals of intensive care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Efficacy of non-invasive ventilation in chronic obstructive pulmonary disease management: a systematic review and meta-analysis of randomized controlled trials.BMC pulmonary medicine · 2025Pooled it
- Effects of extracorporeal COCritical care (London, England) · 2024Pooled it
- Extracorporeal carbon dioxide removal for patients with acute respiratory failure: a systematic review and meta-analysis.Annals of medicine · 2023Pooled it
- Extracorporeal membrane oxygenation for adults with respiratory failure secondary to cardiorespiratory disease: evolving indications and clinical practice.Breathe (Sheffield, England) · 2025Review
- Developing a dichlorosalicylaldehyde-derived fluorescent probe for monitoring glutathione in a cellular pulmonary ventilation model.Frontiers in chemistry · 2025Article
- A review of the clinical value of mechanical ventilators and extracorporeal membrane oxygenation (ECMO) equipment.IPEM-translation · 2024Review
- Is there still a place for ECCOMedizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- VENT-AVOID Trial: Avoiding Acute Hypercapnic Respiratory Failure!American journal of respiratory and critical care medicine · 2024Article
- Extracorporeal Carbon Dioxide Removal in Chronic Obstructive Pulmonary Disease: It Depends on the Objective!American journal of respiratory and critical care medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients presenting with acute hypercapnic respiratory failure due to exacerbations of chronic obstructive pulmonary disease (AECOPD) are typically managed with non-invasive ventilation (NIV). The impact of low-flow extracorporeal carbon dioxide removal (ECCO
methodsOpen-label randomised trial comparing NIV (NIV arm) with ECCO
resultsEighteen patients (median age 67.5, IQR (61.5-71) years; median GOLD stage 3 were enrolled (nine in each arm). Time to NIV discontinuation was shorter with ECCO
interpretationThere is evidence of benefit associated with ECCO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.