Evidence map›Paper›PMID 35445918›Full record

ArticleMolecular neurobiology2022

Age-Dependent Increase in Schmidt-Lanterman Incisures and a Cadm4-Associated Membrane Skeletal Complex in Fatty Acid 2-hydroxylase Deficient Mice: a Mouse Model of Spastic Paraplegia SPG35.

Silvia Jordans, Robert Hardt, Ivonne Becker, Dominic Winter, Lihua Wang-Eckhardt, Matthias Eckhardt

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Silvia Jordans *Department for Pediatric Hematology and Oncology, Center for Pediatrics, University Hospital Bonn, Venusberg-Campus 1, 53117, Bonn, Germany.
Robert Hardt *Institute of Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, Nussallee 11, 53115, Bonn, Germany.
Ivonne BeckerInstitute of Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, Nussallee 11, 53115, Bonn, Germany.
Dominic WinterInstitute of Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, Nussallee 11, 53115, Bonn, Germany.
Lihua Wang-EckhardtInstitute of Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, Nussallee 11, 53115, Bonn, Germany.
Matthias EckhardtInstitute of Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, Nussallee 11, 53115, Bonn, Germany. eckhardt@uni-bonn.de.ORCID http://orcid.org/0000-0003-1964-9064
University of Bonn · DE

Funding

Deutsche Forschungsgemeinschaft SFB645 project B5
6 · The paper itself

Abstract

PNS and CNS myelin contain large amounts of galactocerebroside and sulfatide with 2-hydroxylated fatty acids. The underlying hydroxylation reaction is catalyzed by fatty acid 2-hydroxylase (FA2H). Deficiency in this enzyme causes a complicated hereditary spastic paraplegia, SPG35, which is associated with leukodystrophy. Mass spectrometry-based proteomics of purified myelin isolated from sciatic nerves of Fa2h-deficient (Fa2h

Indexed as

AmidohydrolasesCell Adhesion MoleculesImmunoglobulinsMyelin SheathSpastic Paraplegia, HereditaryAge FactorsAnimalsDisease Models, AnimalFatty Acid Amide HydrolasesFatty AcidsMembrane ProteinsMiceMicrofilament ProteinsMixed Function OxygenasesParaplegiaSchwann CellsAmidohydrolasesCell Adhesion MoleculesEpb4.1l2 protein, mouseFatty Acid Amide HydrolasesFatty AcidsIgsf4c protein, mouseImmunoglobulinsLin7a protein, mouseMembrane ProteinsMicrofilament ProteinsMixed Function OxygenasesMPP6 protein, mouseVesicular Transport ProteinsMyelinSchmidt-Lanterman incisureSpastic paraplegiaSphingolipid

Identifiers

PMID35445918
PMCPMC9167166
OpenAlexW4224223320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.