Evidence map›Paper›PMID 35445888›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2022

Effect of isolation feasibility of non-pulmonary vein foci on efficacy of ablation for atrial fibrillation: comparison of the isolation and focal ablation methods.

Takashi Ikenouchi, Junichi Nitta, Osamu Inaba, Toshikazu Kono, Kazuya Murata, Tomomasa Takamiya, Yukihiro Inamura, Akira Sato, Yutaka Matsumura, Yoshihide Takahashi and 2 more

Abstract read
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In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Usefulness of empiric superior vena cava isolation in paroxysmal atrial fibrillation ablation: a meta-analysis of randomized clinical trials.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Pooled it
  2. Pooled it
  3. Unintended lesion formation and conduction block in the posterior left atrium during pulmonary vein isolation using a pentaspline pulsed field ablation catheter.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
  4. Vein of Marshall ethanol infusion for recurrent atrial fibrillation in patients with durably isolated pulmonary veins.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
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  8. 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Takashi IkenouchiDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo To, 113-8510, Japan. i.tks.music@gmail.com.ORCID http://orcid.org/0000-0002-4007-320X
Junichi NittaDepartment of Cardiology, Sakakibara Heart Institute, 3-16-1 Asahicho, Fuchu-shi, Tokyo To, 183-0003, Japan.
Osamu InabaDepartment of Cardiology, Japanese Red Cross Saitama Hospital, 1-5 Shintoshin, Chuo-kuSaitama Prefecture, Saitama City, 330-8553, Japan.
Toshikazu KonoDepartment of Cardiology, Japanese Red Cross Saitama Hospital, 1-5 Shintoshin, Chuo-kuSaitama Prefecture, Saitama City, 330-8553, Japan.
Kazuya MurataDepartment of Cardiology, Japanese Red Cross Saitama Hospital, 1-5 Shintoshin, Chuo-kuSaitama Prefecture, Saitama City, 330-8553, Japan.
Tomomasa TakamiyaDepartment of Cardiology, Japanese Red Cross Saitama Hospital, 1-5 Shintoshin, Chuo-kuSaitama Prefecture, Saitama City, 330-8553, Japan.
Yukihiro InamuraDepartment of Cardiology, Japanese Red Cross Saitama Hospital, 1-5 Shintoshin, Chuo-kuSaitama Prefecture, Saitama City, 330-8553, Japan.
Akira SatoDepartment of Cardiology, Japanese Red Cross Saitama Hospital, 1-5 Shintoshin, Chuo-kuSaitama Prefecture, Saitama City, 330-8553, Japan.
Yutaka MatsumuraDepartment of Cardiology, Japanese Red Cross Saitama Hospital, 1-5 Shintoshin, Chuo-kuSaitama Prefecture, Saitama City, 330-8553, Japan.
Yoshihide TakahashiDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo To, 113-8510, Japan.
Masahiko GoyaDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo To, 113-8510, Japan.
Tetsuo SasanoDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo To, 113-8510, Japan.
Saitama Prefecture · JPTokyo Medical and Dental University · JPSakakibara Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAtrial fibrillation (AF) mainly originates from the pulmonary vein (PV). However, some AF triggers originate from other sites, namely non-PV foci, which are related to recurrence after AF ablation. This study aimed to evaluate the effects of isolation feasibility (isolability) of non-PV foci on the efficacy of AF ablation.

methodsOverall, 1855 patients with AF (age, 64.6 ± 10.9 years; 82% paroxysmal) underwent PV isolation, followed by induction and ablation of non-PV foci. Among them, 545 (29%) patients had non-PV foci; these patients were categorized into those with isolable non-PV foci (n = 196, 36%) and those with non-isolable non-PV foci (n = 349, 64%).

resultsDuring a mean follow-up of 31.2 ± 15.6 months, recurrence was higher in the non-isolable group than in the isolable group (34% vs. 19%, P < 0.01). Kaplan-Meier analyses revealed a significantly better 1-year clinical outcome in the isolable group than in the non-isolable group (88.0% vs. 78.4%, P < 0.001; hazard ratio (HR), 0.56; 95% confidence interval (CI), 0.39-0.81). This outcome was not inferior to that of patients without non-PV foci (88.3% vs. 90.8%, P = 0.81). The non-isolable group showed poorer clinical outcomes than patients without non-PV foci (78.4% vs. 90.8%, P < 0.001; HR, 1.37; 95% CI, 1.22-1.53). Cox regression analysis revealed that isolability (HR, 0.56; 95% CI, 0.36-0.89) and unmappability (HR, 2.89; 95% CI, 1.55-5.37) of non-PV foci were significant predictors of arrhythmia recurrence.

conclusionThe isolability of non-PV foci was a significant factor affecting the achievement of better clinical outcomes following AF ablation in patients with non-PV foci.

Indexed as

Atrial FibrillationCatheter AblationPulmonary VeinsAgedFeasibility StudiesHumansMiddle AgedRecurrenceTreatment OutcomeAtrial fibrillationClinical outcomeFocal ablationIsolation feasibilityNon-pulmonary vein foci

Identifiers

PMID35445888
OpenAlexW4224291479

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.