ReviewSeminars in immunopathology2022
Narcolepsy: a model interaction between immune system, nervous system, and sleep-wake regulation.
Review in Seminars in immunopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Identification and Characterization of Human Autoreactive T Cells for Autoimmune Research.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Rapid Eye Movement Sleep-Related Indicators with Promising Performance in Diagnosing Narcolepsy.Nature and science of sleep · 2026Article
- Electroacupuncture Attenuates Neuroinflammation in PCPA-Induced Insomnia Rats by Suppressing the TLR4/MyD88/NF-κB p65 Pathway and M1 Microglial Activation.Neuropsychiatric disease and treatment · 2026Article
- Narcolepsy Associated With Streptococcal Infection: A Case Report and Literature Review.Clinical case reports · 2025Article
- Hypothalamic functional connectivity, depressive symptoms, and post-treatment SOREMPs in narcolepsy type 1: links to sleep latency and mediation mechanisms.Translational psychiatry · 2025Article
- Animal Models of Narcolepsy: From Orexin Deficiency to Immune Mechanisms and Regenerative Therapies.Current issues in molecular biology · 2025Review
- Global estimates of vaccine-associated narcolepsy from 1967 to 2023.Scientific reports · 2025Article
- Effects of music on post-stroke sleep disorders and treatment perspectives: review and narrative synthesis.Frontiers in human neuroscience · 2025Review
- Review
- The immunopathogenesis of narcolepsy type 1.Nature reviews. Immunology · 2024Review
- Sleep disorders during pregnancy: an underestimated risk factor for gestational diabetes mellitus.Endocrine · 2024Review
- Larger hypothalamic volume in narcolepsy type 1.Sleep · 2023Article
- An Update on Kleine-Levin Syndrome.Current sleep medicine reports · 2023Review
- Editorial: Knocking on neuroimmunology's doors: an entrechat concerning the immune system balance and its cell metabolism orchestration.Frontiers in immunology · 2023Article
- Autoimmunity and SARS-CoV-2 infection: Unraveling the link in neurological disorders.European journal of immunology · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Narcolepsy is a rare chronic neurological disorder characterized by an irresistible excessive daytime sleepiness and cataplexy. The disease is considered to be the result of the selective disruption of neuronal cells in the lateral hypothalamus expressing the neuropeptide hypocretin, which controls the sleep-wake cycle. Diagnosis and management of narcolepsy represent still a substantial medical challenge due to the large heterogeneity in the clinical manifestation of the disease as well as to the lack of understanding of the underlying pathophysiological mechanisms. However, significant advances have been made in the last years, thus opening new perspective in the field. This review describes the current knowledge of clinical presentation and pathology of narcolepsy as well as the existing diagnostic criteria and therapeutic intervention for the disease management. Recent evidence on the potential immune-mediated mechanisms that may underpin the disease establishment and progression are also highlighted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.