Evidence map›Paper›PMID 35445828›Full record

ArticleArchives of toxicology2022

Reversal of genetic brain iron accumulation by N,N'-bis(2-mercaptoethyl)isophthalamide, a lipophilic metal chelator, in mice.

Ruiying Cheng, Rajitha Gadde, Yingfang Fan, Neha Kulkarni, Nachiket Shevale, Kai Bao, Hak Soo Choi, Swati Betharia, Jonghan Kim

Abstract read
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In one paragraph

Article in Archives of toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ruiying Cheng *Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USA.
Rajitha Gadde *Department of Pharmaceutical Sciences, School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA.
Yingfang FanDepartment of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Neha KulkarniDepartment of Pharmaceutical Sciences, School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA.
Nachiket ShevaleDepartment of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
Kai BaoGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Hak Soo ChoiGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Swati BethariaDepartment of Pharmaceutical Sciences, School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA. Swati.Betharia@mcphs.edu.
Jonghan KimDepartment of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USA. Jonghan_Kim@uml.edu.ORCID http://orcid.org/0000-0001-8226-7427
Massachusetts College of Pharmacy and Health Sciences · USNortheastern University · USHarvard University · USUniversity of Massachusetts Lowell · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) is a novel lipophilic metal chelator and antioxidant used in mercury poisoning. Recent studies have suggested that NBMI may also bind to other metals such as lead and iron. Since NBMI can enter the brain, we evaluated if NBMI removes excess iron from the iron-loaded brain and ameliorates iron-induced oxidative stress. First, NBMI exhibited preferential binding to ferrous (Fe

Indexed as

NeuroblastomaAnimalsBenzene DerivativesBrainChelating AgentsHumansIronMiceSulfhydryl CompoundsBenzene DerivativesChelating AgentsIronN,N'-Bis(2-mercaptoethyl)isophthalamideSulfhydryl CompoundsIron chelationIron overloadLabile ironNeurodegenerative diseaseNeuroprotection

Identifiers

PMID35445828
OpenAlexW4224212919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.