Evidence map›Paper›PMID 35445787›Full record

ArticleAutism research : official journal of the International Society for Autism Research2022

Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities.

Stephania Assimopoulos, Christopher Hammill, Darren J Fernandes, Tara Leigh Spencer Noakes, Yu-Qing Zhou, Lauryl M J Nutter, Jacob Ellegood, Evdokia Anagnostou, John G Sled, Jason P Lerch

Open access · greenAbstract read
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Biological subtyping of autism via cross-species fMRI.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. The pleiotropic spectrum of proximal 16p11.2 CNVs.American journal of human genetics · 2024
    Review
  8. Article
  9. Article
  10. The emerging roles of Shank3 in cardiac function and dysfunction.Frontiers in cell and developmental biology · 2023
    Review
  11. Article
  12. Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities.Autism research : official journal of the International Society for Autism Research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Stephania AssimopoulosMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-7321-6297
Christopher HammillMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-9823-2827
Darren J FernandesMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
Tara Leigh Spencer NoakesMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
Yu-Qing ZhouMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
Lauryl M J NutterSickkids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-9619-146X
Jacob EllegoodMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
Evdokia AnagnostouBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
John G SledMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
Jason P LerchMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
Hospital for Sick Children · CAUniversity of Toronto · CAHolland Bloorview Kids Rehabilitation Hospital · CASickKids Foundation · CA

Funding

CIHR
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked on a functional and genetic level. Most work has investigated CHD-related neurodevelopmental abnormalities. Cardiac abnormalities in ASD have been less studied. We investigated the prevalence of cardiac comorbidities relative to ASD genetic contributors. Using high frequency ultrasound imaging, we screened 9 ASD-related genetic mouse models (Arid1b

Indexed as

Autism Spectrum DisorderHeart Defects, CongenitalAnimalsDisease Models, AnimalFragile X Messenger Ribonucleoprotein 1MiceMicrofilament ProteinsNerve Tissue ProteinsPhenotypeTranscription FactorsFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Microfilament ProteinsNerve Tissue ProteinsShank3 protein, mouseTranscription Factorsautismcardiac phenotype/cardiologycomorbiditiesgenetic mouse modelsphenotypingultrasound biomicroscopy

Identifiers

PMID35445787
PMCPMC9325472
OpenAlexW4226148856

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.