Evidence map›Paper›PMID 35445592›Full record

ArticleJournal of biomedical optics2022

Two-step verification method for Monte Carlo codes in biomedical optics applications.

Angelo Sassaroli, Federico Tommasi, Stefano Cavalieri, Lorenzo Fini, André Liemert, Alwin Kienle, Tiziano Binzoni, Fabrizio Martelli

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Angelo SassaroliTufts University, Department of Biomedical Engineering, Medford, Massachusetts, United States.
Federico TommasiDipartimento di Fisica e Astronomia dell'Università degli Studi di Firenze, Sesto Fiorentino, Italy.
Stefano CavalieriDipartimento di Fisica e Astronomia dell'Università degli Studi di Firenze, Sesto Fiorentino, Italy.
Lorenzo FiniDipartimento di Fisica e Astronomia dell'Università degli Studi di Firenze, Sesto Fiorentino, Italy.
André LiemertInstitut für Lasertechnologien in der Medizin und Meßtechnik an der Universität Ulm (ILM), Ulm, Germany.
Alwin KienleInstitut für Lasertechnologien in der Medizin und Meßtechnik an der Universität Ulm (ILM), Ulm, Germany.
Tiziano BinzoniUniversity of Geneva, Department of Basic Neurosciences, Geneva, Switzerland.
Fabrizio MartelliDipartimento di Fisica e Astronomia dell'Università degli Studi di Firenze, Sesto Fiorentino, Italy.

Funding

Coherent hemodynamics spectroscopy for cerebral autoregulation and blood flowR01NS095334 · NINDS · TUFTS UNIVERSITY MEDFORD · PI FANTINI, SERGIO · 2016 to 2020
$2.6M
Dual-slope method for enhanced depth sensitivity in frequency-domain near-infrared spectroscopyR01EB029414 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI SERGIO FANTINI · 2021 to 2026
$2.5M
NIBIB NIH HHS R01 EB029414NINDS NIH HHS R01 NS095334
6 · The paper itself

Abstract

significanceCode verification is an unavoidable step prior to using a Monte Carlo (MC) code. Indeed, in biomedical optics, a widespread verification procedure for MC codes is still missing. Analytical benchmarks that can be easily used for the verification of different MC routines offer an important resource.

aimWe aim to provide a two-step verification procedure for MC codes enabling the two main tasks of an MC simulator: (1) the generation of photons' trajectories and (2) the intersections of trajectories with boundaries separating the regions with different optical properties. The proposed method is purely based on elementary analytical benchmarks, therefore, the correctness of an MC code can be assessed with a one-sample t-test. APPROACH: The two-step verification is based on the following two analytical benchmarks: (1) the exact analytical formulas for the statistical moments of the spatial coordinates where the scattering events occur in an infinite medium and (2) the exact invariant solutions of the radiative transfer equation for radiance, fluence rate, and mean path length in media subjected to a Lambertian illumination.

resultsWe carried out a wide set of comparisons between MC results and the two analytical benchmarks for a wide range of optical properties (from non-scattering to highly scattering media, with different types of scattering functions) in an infinite non-absorbing medium (step 1) and in a non-absorbing slab (step 2). The deviations between MC results and exact analytical values are usually within two standard errors (i.e., t-tests not rejected at a 5% level of significance). The comparisons show that the accuracy of the verification increases with the number of simulated trajectories so that, in principle, an arbitrary accuracy can be obtained.

conclusionsGiven the simplicity of the verification method proposed, we envision that it can be widely used in the field of biomedical optics.

Indexed as

Optics and PhotonicsPhotonsMonte Carlo Methodanalytical benchmarksbiomedical opticsforward solversMonte Carlo methodradiative transfer equationverification procedure

Identifiers

PMID35445592
PMCPMC9020254

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.