Evidence map›Paper›PMID 35445551›Full record

ArticleZoonoses and public health2022

Evidence of influenza A infection and risk of transmission between pigs and farmworkers.

Gustavo Lopez-Moreno, Peter Davies, My Yang, Marie R Culhane, Cesar A Corzo, Chong Li, Aaron Rendahl, Montserrat Torremorell

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zoonoses and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  19. Infectious Diseases and Clinical Xenotransplantation.Emerging infectious diseases · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gustavo Lopez-MorenoVeterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
Peter DaviesVeterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.ORCID 0000-0002-0397-7293
My YangVeterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
Marie R CulhaneVeterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
Cesar A CorzoVeterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
Chong LiVeterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
Aaron RendahlVeterinary and Biomedical Sciences Department, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
Montserrat TorremorellVeterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.ORCID 0000-0002-9626-6537
University of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interspecies transmission of influenza A virus (IAV) between pigs and people represents a threat to both animal and public health. To better understand the risks of influenza transmission at the human-animal interface, we evaluated 1) the rate of IAV detection in swine farmworkers before and after work during two human influenza seasons, 2) assessed risk factors associated with IAV detection in farmworkers and 3) characterized the genetic sequences of IAV detected in both workers and pigs. Of 58 workers providing nasal passage samples during 8-week periods during the 2017/18 and 2018/19 influenza seasons, 33 (57%) tested positive by rRT-PCR at least once. Sixteen (27%) workers tested positive before work and 24 (41%) after work. At the sample level, 58 of 1,785 nasal swabs (3.2%) tested rRT-PCR positive, of which 20 of 898 (2.2%) were collected prior to work and 38 of 887 (4.3%) after work. Although farmworkers were more likely to test positive at the end of the working day (OR = 1.98, 95% CI 1.14-3.41), there were no influenza-like illness (ILI) symptoms, or other risk indicators, associated with IAV detection before or after reporting to work. Direct whole-genome sequencing from samples obtained from worker nasal passages indicated evidence of infection of a worker with pandemic 2009 H1N1 of human-origin IAV (H1-pdm 1A 3.3.2) when reporting to work, and exposure of several workers to a swine-origin IAV (H1-alpha 1A 1.1) circulating in the pigs on the farm where they were employed. Our study provides evidence of 1) risk of IAV transmission between pigs and people, 2) pandemic H1N1 IAV infected workers reporting to work and 3) workers exposed to swine harbouring swine-origin IAV in their nasal passages temporarily. Overall, our results emphasize the need to implement surveillance and transmission preventive protocols at the pig/human interface.

Indexed as

Influenza A virusInfluenza A Virus, H1N1 SubtypeInfluenza, HumanOrthomyxoviridae InfectionsSwine DiseasesAnimalsFarmersHumansSwinefarmworkersinfluenzaswinetransmission

Identifiers

PMID35445551
PMCPMC9546022
OpenAlexW4224221899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.