Evidence map›Paper›PMID 35445421›Full record

ArticleHepatology (Baltimore, Md.)2022

Identification of the chloride channel, leucine-rich repeat-containing protein 8, subfamily a (LRRC8A), in mouse cholangiocytes.

Nikolay Shcheynikov, Kristy Boggs, Anthony Green, Andrew P Feranchak

Open access · greenAbstract read
In one paragraph

Article in Hepatology (Baltimore, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Nikolay ShcheynikovDepartment of Pediatrics, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kristy BoggsDepartment of Pediatrics, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-1029-0182
Anthony GreenTissue and Research Pathology Core, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Andrew P FeranchakDepartment of Pediatrics, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Children's Hospital of Pittsburgh · USUniversity of Pittsburgh · USUPMC Hillman Cancer Center · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVID A GELLER · 2019 to 2026
$10.9M
Mechanosensitive Signaling and Cholangiocyte SecretionR01DK078587 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI FERANCHAK, ANDREW P · 2008 to 2019
$3.6M
NCI NIH HHS P30 CA047904NIDDK NIH HHS P30 DK120531NIDDK NIH HHS R01 DK078587
6 · The paper itself

Abstract

BACKGROUND AND

aimsChloride (Cl APPROACH AND

resultsStudies were performed in mouse small (MSC) and large (MLC) cholangiocytes. Membrane Cl

conclusionThese results demonstrate that LRRC8A is functionally present in mouse BECs, contributes to volume-activated Cl

Indexed as

Chloride ChannelsCystic Fibrosis Transmembrane Conductance RegulatorAnimalsChloridesEpithelial CellsLeucineLeucine-Rich Repeat ProteinsMembrane ProteinsMiceRNA, Small InterferingChloride ChannelsChloridesCystic Fibrosis Transmembrane Conductance RegulatorLeucineLeucine-Rich Repeat ProteinsLRRC8A protein, mouseMembrane ProteinsRNA, Small Interfering

Identifiers

PMID35445421
PMCPMC10126881
OpenAlexW4224238572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.