ReviewJournal of anatomy2023
Advancements in left ventricular assist devices to prevent pump thrombosis and blood coagulopathy.
Review in Journal of anatomy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Minimally Invasive Left Ventricular Assist Device Implantation: A Systematic Review of Current Evidence on Clinical Outcomes and Surgical Approaches.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Biventricular Assist Devices Versus Total Artificial Heart as Bridge-to-Transplantation Strategies: A Systematic Review and Meta-analysis.Cardiovascular engineering and technology · 2026Review
- Elective Total Joint Replacement in Patients With Left Ventricular Assist Devices: A Modern Case Series and Systematic Review.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2026Article
- Embolic Transport in LVAD Outflow: An Experimental Study Using Patient-Specific and Idealized Aortic Models.Annals of biomedical engineering · 2026Article
- Preoperative Left Ventricular Thrombus and Midterm Outcomes Following Left Ventricular Assist Device Support.Journal of clinical medicine · 2026Article
- Thrombosis in Neuromuscular Medicine: Current Evidence, Unmet Needs, and Future Directions.Journal of clinical medicine · 2026Review
- Aortic Root Thrombosis With Multivessel Coronary Embolism Following Left Ventricular Assist Device Implantation.JACC. Case reports · 2026Article
- Successful allogeneic stem cell transplant in a patient with a left ventricular assist device: a novel case report.Annals of hematology · 2026Article
- Multiobjective Comprehensive Evaluation and Optimization of Interventional Blood Pump Impeller.Cardiovascular engineering and technology · 2026Article
- Evolving anticoagulation paradigms in left ventricular assist device (LVAD) patients: a focus on direct oral anticoagulants.Heart failure reviews · 2025Review
- Materials Advances in Devices for Heart Disease Interventions.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Advances in Mechanical Circulatory Support (MCS): Literature Review.Biomedicines · 2025Review
- Outcomes of Left Ventricular Assist Devices as Destination Therapy: A Systematic Review with Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- Recent Developments in Ventricular Assist Device Therapy.Reviews in cardiovascular medicine · 2025Review
- Advancing LVAD Technology: Overcoming Challenges and Shaping the Future of Mechanical Circulatory Support.Journal of clinical medicine · 2024Review
- Biosensors with left ventricular assist devices.Heart failure reviews · 2024Review
- Novel para-aortic cardiac assistance using a pre-stretched dielectric elastomer actuator.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Titanium is a potent inducer of contact activation: implications for intravascular devices.Journal of thrombosis and haemostasis : JTH · 2023Article
- Hemodynamic Evaluation of a Centrifugal Left Atrial Decompression Pump for Heart Failure with Preserved Ejection Fraction.Bioengineering (Basel, Switzerland) · 2023Article
- Neurologic Complications in Patients With Left Ventricular Assist Devices.The Canadian journal of cardiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanical circulatory support (MCS) devices, such as left ventricular assist devices (LVADs) are very useful in improving outcomes in patients with advanced-stage heart failure. Despite recent advances in LVAD development, pump thrombosis is one of the most severe adverse events caused by LVADs. The contact of blood with artificial materials of LVAD pumps and cannulas triggers the coagulation cascade. Heat spots, for example, produced by mechanical bearings are often subjected to thrombus build-up when low-flow situations impair washout and thus the necessary cooling does not happen. The formation of thrombus in an LVAD may compromise its function, causing a drop in flow and pumping power leading to failure of the LVAD, if left unattended. If a clot becomes dislodged and circulates in the bloodstream, it may disturb the flow or occlude the blood vessels in vital organs and cause internal damage that could be fatal, for example, ischemic stroke. That is why patients with LVADs are on anti-coagulant medication. However, the anti-coagulants can cause a set of issues for the patient-an example of gastrointestinal (GI) bleeding is given in illustration. On account of this, these devices are only used as a last resort in clinical practice. It is, therefore, necessary to develop devices with better mechanics of blood flow, performance and hemocompatibility. This paper discusses the development of LVADs through landmark clinical trials in detail and describes the evolution of device design to reduce the risk of pump thrombosis and achieve better hemocompatibility. Whilst driveline infection, right heart failure and arrhythmias have been recognised as LVAD-related complications, this paper focuses on complications related to pump thrombosis, especially blood coagulopathy in detail and potential strategies to mitigate this complication. Furthermore, it also discusses the LVAD implantation techniques and their anatomical challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.