Evidence map›Paper›PMID 35445370›Full record

ArticleJournal of autism and developmental disorders2023

Sex- and age-related differences in autistic behaviours in children with neurofibromatosis type 1.

Anita K Chisholm, Francesca Lami, Kristina M Haebich, Alex Ure, Amanda Brignell, Tiba Maloof, Natalie A Pride, Karin S Walsh, Alice Maier, Melissa Rouel and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Neurobehavioral sex-related differences in Nf1Biology of sex differences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Anita K ChisholmMurdoch Children's Research Institute, 50 Flemington Road, 3052, Parkville, VIC, Australia.
Francesca LamiMurdoch Children's Research Institute, 50 Flemington Road, 3052, Parkville, VIC, Australia.
Kristina M HaebichMurdoch Children's Research Institute, 50 Flemington Road, 3052, Parkville, VIC, Australia.
Alex UreMurdoch Children's Research Institute, 50 Flemington Road, 3052, Parkville, VIC, Australia.
Amanda BrignellMurdoch Children's Research Institute, 50 Flemington Road, 3052, Parkville, VIC, Australia.
Tiba MaloofDepartment of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, 3010, Parkville, VIC, Australia.
Natalie A PrideKids Neuroscience Centre, The Children's Hospital at Westmead, 178A Hawkesbury Road, 2145, Westmead, NSW, Australia.
Karin S WalshCenter for Neuroscience and Behavioral Medicine, Children's National Hospital, Michigan Avenue NW, 20310, Washington, DC, United States.
Alice MaierMurdoch Children's Research Institute, 50 Flemington Road, 3052, Parkville, VIC, Australia.
Melissa RouelKids Neuroscience Centre, The Children's Hospital at Westmead, 178A Hawkesbury Road, 2145, Westmead, NSW, Australia.
Yael GranaderCenter for Neuroscience and Behavioral Medicine, Children's National Hospital, Michigan Avenue NW, 20310, Washington, DC, United States.
Belinda BartonKids Neuroscience Centre, The Children's Hospital at Westmead, 178A Hawkesbury Road, 2145, Westmead, NSW, Australia.
Hayley DarkeMurdoch Children's Research Institute, 50 Flemington Road, 3052, Parkville, VIC, Australia.
Ian FuelscherSchool of Psychology, Cognitive Neuroscience Unit, Deakin University, 221 Burwood Highway, 3125, Burwood, VIC, Australia.
Gabriel DabscheckMurdoch Children's Research Institute, 50 Flemington Road, 3052, Parkville, VIC, Australia.
Vicki A AndersonMurdoch Children's Research Institute, 50 Flemington Road, 3052, Parkville, VIC, Australia.
Katrina WilliamsMurdoch Children's Research Institute, 50 Flemington Road, 3052, Parkville, VIC, Australia.
Kathryn N NorthMurdoch Children's Research Institute, 50 Flemington Road, 3052, Parkville, VIC, Australia.
Jonathan M PayneMurdoch Children's Research Institute, 50 Flemington Road, 3052, Parkville, VIC, Australia. Jonathan.payne@mcri.edu.au.ORCID http://orcid.org/0000-0001-9565-3845

Funding

murdoch children's research institute murdoch children's research institutenational health and medical research council national health and medical research councilu.s. department of defense W81XWH-15-1-0619
6 · The paper itself

Abstract

This study investigated sex and age differences in autistic behaviours in children with neurofibromatosis type 1 (NF1) who scored within the clinical range on the Social Responsiveness Scale - Second Edition (T score ≥ 60). Thirty-four males and 28 females (3-16 years) were assessed with the Autism Diagnostic Observation Schedule - Second Edition and Autism Diagnostic Interview - Revised. Across both measures, males exhibited greater social communication deficits relative to females. Age-related abatement of social communication difficulties was observed for males but not females. Conversely, no sex differences were found for restricted/repetitive behaviours, which were stable over time for both males and females. The findings are discussed within the context of broader neurodevelopmental considerations that are common in NF1.

Indexed as

Autism Spectrum DisorderAutistic DisorderNeurofibromatosis 1ChildCommunicationHumansLanguageMaleAge-related differencesAutismAutisticChildrenNeurofibromatosis type 1Sex differences

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.