Evidence map›Paper›PMID 35445369›Full record

ArticleJournal of autism and developmental disorders2023

Williams syndrome: reduced orienting to other's eyes in a hypersocial phenotype.

Johan Lundin Kleberg, Deborah Riby, Christine Fawcett, Hanna Björlin Avdic, Matilda A Frick, Karin C Brocki, Jens Högström, Eva Serlachius, Ann Nordgren, Charlotte Willfors

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Johan Lundin KlebergCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute and Stockholm Health Care Services, Region Stockholm, Sweden. johan.lundin.kleberg@ki.se.ORCID http://orcid.org/0000-0001-8222-1699
Deborah RibyCentre for Developmental Disorders, Department of Psychology, Durham University, Durham, United Kingdom.
Christine FawcettDepartment of Psychology, Uppsala University, Uppsala, Sweden.
Hanna Björlin AvdicCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute and Stockholm Health Care Services, Region Stockholm, Sweden.
Matilda A FrickDepartment of Psychology, Uppsala University, Uppsala, Sweden.
Karin C BrockiDepartment of Psychology, Uppsala University, Uppsala, Sweden.
Jens HögströmCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute and Stockholm Health Care Services, Region Stockholm, Sweden.
Eva SerlachiusCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute and Stockholm Health Care Services, Region Stockholm, Sweden.
Ann NordgrenDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Charlotte WillforsDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

Funding

åke wiberg stiftelse åke wiberg stiftelsebertil hållstens forskningsstiftelse bertil hållstens forskningsstiftelsefredrik och ingrid thurings stiftelse fredrik och ingrid thurings stiftelsehjärnfonden hjärnfondenh.k.h. kronprinsessan lovisas förening för barnasjukvård h.k.h. kronprinsessan lovisas förening för barnasjukvårdLinnéa och Josef Carlssons Stiftelse 224-20210308-027Sävstaholm Foundation Sävstaholm Foundationstiftelsen sunnerdahls handikappfond stiftelsen sunnerdahls handikappfond
6 · The paper itself

Abstract

Williams syndrome (WS) is a rare genetic condition associated with high sociability, intellectual disability, and social cognitive challenges. Attention to others' eyes is crucial for social understanding. Orienting to, and from other's eyes was studied in WS (n = 37, mean age = 23, age range 9-53). The WS group was compared to a typically developing comparison participants (n = 167) in stratified age groups from infancy to adulthood. Typically developing children and adults were quicker and more likely to orient to eyes than the mouth. This bias was absent in WS. The WS group had reduced peak saccadic velocities, indicating hypo-arousal. The current study indicates reduced orienting to others' eyes in WS, which may affect social interaction skills.

Indexed as

Autism Spectrum DisorderWilliams SyndromeHumansPhenotypeArousalAttention to eyesEye trackingSocial motivationSocial orientingWilliams syndrome

Identifiers

PMID35445369
PMCPMC9020553

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.