Evidence map›Paper›PMID 35445358›Full record

ArticleGeroScience2022

Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults.

Wan-Hsuan Lu, Kelly Virecoulon Giudici, John E Morley, Sophie Guyonnet, Angelo Parini, Geetika Aggarwal, Andrew D Nguyen, Yan Li, Randall J Bateman, Bruno Vellas and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Wan-Hsuan LuGerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), 31000, Toulouse, France.ORCID 0000-0001-7824-4214
Kelly Virecoulon GiudiciGerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), 31000, Toulouse, France.
John E MorleyDivision of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA.
Sophie GuyonnetGerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), 31000, Toulouse, France.
Angelo PariniInstitute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400, Toulouse, France.
Geetika AggarwalDivision of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA.
Andrew D NguyenDivision of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA.
Yan LiDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Randall J BatemanDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Bruno VellasGerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), 31000, Toulouse, France.
Philipe de Souto BarretoGerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), 31000, Toulouse, France.
MAPT/DSA Group
Université Toulouse III - Paul Sabatier · FRWashington University in St. Louis · USCentre Hospitalier Universitaire de Toulouse · FRInserm · FR

Funding

Blood amyloid-beta relationship with amyloid plaques and CSF amyloid-betaRF1AG061900 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2019 to 2020
$6.9M
NIA NIH HHS RF1 AG061900
6 · The paper itself

Abstract

We investigated combining a core AD neuropathology measure (plasma amyloid-beta [Aβ]

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersClinical Trials as TopicGeroscienceHumansIncidenceAmyloid beta-PeptidesBiomarkersAgingAlzheimer’s diseaseAmyloid-betaCognitive declineInflammationNeurodegeneration

Identifiers

PMID35445358
PMCPMC9213609
OpenAlexW4224243989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.