Evidence map›Paper›PMID 35445345›Full record

ArticleActa diabetologica2022

Urinary interleukin-9 in youth with type 1 diabetes mellitus.

Julie Semenchuk, Katie Sullivan, Rahim Moineddin, Farid Mahmud, Allison Dart, Brandy Wicklow, Fengxia Xiao, Thalia Medeiros, James Scholey, Dylan Burger

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta diabetologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. CD4Frontiers in immunology · 2026
    Review
  2. Review
  3. Role of Interleukins in Type 1 and Type 2 Diabetes.Diagnostics (Basel, Switzerland) · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Julie Semenchuk *Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada. julie.semenchuk@mail.utoronto.ca.ORCID http://orcid.org/0000-0002-2933-2741
Katie Sullivan *Department of Medicine, Renal and Hypertension Division, University of Pennsylvania, Philadelphia, USA.ORCID http://orcid.org/0000-0002-2606-733X
Rahim MoineddinDepartment of Family and Community Medicine, University of Toronto, Toronto, Canada.ORCID http://orcid.org/0000-0002-5506-084X
Farid MahmudDepartment of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada.ORCID http://orcid.org/0000-0002-3557-3584
Allison DartDepartment of Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, Diabetes Research Envisioned and Accomplished in Manitoba Research Team, University of Manitoba, Winnipeg, Canada.ORCID http://orcid.org/0000-0002-4718-9408
Brandy WicklowDepartment of Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, Diabetes Research Envisioned and Accomplished in Manitoba Research Team, University of Manitoba, Winnipeg, Canada.
Fengxia XiaoDepartment of Medicine, Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.
Thalia MedeirosDepartment of Medicine, Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.
James Scholey *Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada.ORCID http://orcid.org/0000-0001-5591-2267
Dylan Burger *Department of Medicine, Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.ORCID http://orcid.org/0000-0003-3951-2911
University of Ottawa · CAChildren's Hospital Research Institute of Manitoba · CAUniversity Health Network · CAUniversity of Toronto · CAUniversity of Pennsylvania · US

Funding

CIHR MOP-343810
6 · The paper itself

Abstract

aimsInterleukin-9 (IL-9) attenuates podocyte injury in experimental kidney disease, but its role in diabetic nephropathy is unknown. We sought to relate urinary IL-9 levels to the release of podocyte-derived extracellular vesicles (EVs) in youth with type 1 diabetes. We related urinary IL-9 levels to clinical variables and studied interactions between urinary IL-9, vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6) on urinary albumin/creatinine ratio (ACR) a functional measure of podocyte injury.

methodsWe performed an analysis of urine samples and clinical data from a cohort of youth with type 1 diabetes (n = 53). Cytokines were measured using a Luminex platform (Eve Technologies), and nanoscale flow cytometry was employed to quantify urinary podocyte-derived EVs. All urinary measures were normalized to urinary creatinine.

resultsMean age was 14.7 ± 1.6 years, and the mean time from diagnosis was 6.7 ± 2.9 years. Mean HbA1c was 70.3 ± 13.9 mmol/mol, mean ACR was 1.3 ± 1.9 mg/mmol, and mean eGFR was 140.3 ± 32.6 ml/min/1.73 m

conclusionsIL-9 is associated with podocyte injury in early type 1 diabetes, and there are complex interactions between urinary IL-9, inflammatory cytokines and ACR.

Indexed as

Diabetes Mellitus, Type 1Diabetic NephropathiesInterleukin-6Interleukin-9AdolescentAlbuminuriaBiomarkersCreatinineCytokinesGlycated HemoglobinHumansTumor Necrosis Factor-alphaVascular Endothelial Growth Factor ABiomarkersCreatinineCytokinesGlycated HemoglobinIL9 protein, humanInterleukin-6Interleukin-9Tumor Necrosis Factor-alphaVascular Endothelial Growth Factor AAlbuminuriaCytokinesExtracellular vesicleIL9PodocyteType 1 diabetes mellitus

Identifiers

PMID35445345
PMCPMC9156513
OpenAlexW4224265386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.