Evidence map›Paper›PMID 35445297›Full record

ReviewAnnals of biomedical engineering2022

Machine Learning for Cardiovascular Biomechanics Modeling: Challenges and Beyond.

Amirhossein Arzani, Jian-Xun Wang, Michael S Sacks, Shawn C Shadden

Abstract readReview
PubMed Publisher
In one paragraph

Review in Annals of biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Uncover Hidden Physical Information of Soft Matter by Observing Large Deformation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Machine learning: a new era for cardiovascular pregnancy physiology and cardio-obstetrics research.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amirhossein ArzaniDepartment of Mechanical Engineering, Northern Arizona University, Flagstaff, AZ, 86011, USA. amir.arzani@nau.edu.ORCID http://orcid.org/0000-0002-3706-7909
Jian-Xun WangDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, USA.
Michael S SacksJames T. Willerson Center for Cardiovascular Modeling and Simulation, Oden Institute for Computational Engineering and Sciences, Austin, TX, USA.
Shawn C ShaddenDepartment of Mechanical Engineering, University of California Berkeley, Berkeley, CA, USA.

Funding

American Heart Association 18EIA33900046National Science Foundation 1934300National Science Foundation 2047127National Science Foundation 2103434
6 · The paper itself

Abstract

Recent progress in machine learning (ML), together with advanced computational power, have provided new research opportunities in cardiovascular modeling. While classifying patient outcomes and medical image segmentation with ML have already shown significant promising results, ML for the prediction of biomechanics such as blood flow or tissue dynamics is in its infancy. This perspective article discusses some of the challenges in using ML for replacing well-established physics-based models in cardiovascular biomechanics. Specifically, we discuss the large landscape of input features in 3D patient-specific modeling as well as the high-dimensional output space of field variables that vary in space and time. We argue that the end purpose of such ML models needs to be clearly defined and the tradeoff between the loss in accuracy and the gained speedup carefully interpreted in the context of translational modeling. We also discuss several exciting venues where ML could be strategically used to augment traditional physics-based modeling in cardiovascular biomechanics. In these applications, ML is not replacing physics-based modeling, but providing opportunities to solve ill-defined problems, improve measurement data quality, enable a solution to computationally expensive problems, and interpret complex spatiotemporal data by extracting hidden patterns. In summary, we suggest a strategic integration of ML in cardiovascular biomechanics modeling where the ML model is not the end goal but rather a tool to facilitate enhanced modeling.

Indexed as

Cardiovascular SystemMachine LearningBiomechanical PhenomenaHumansLungPatient-Specific ModelingData-driven modelingDeep learningHemodynamicsPhysics-based modelingScientific machine learning

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.