Evidence map›Paper›PMID 35445214›Full record

ArticleACS polymers Au2022

Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices.

Rubina Ajdary, Guillermo Reyes, Jani Kuula, Eija Raussi-Lehto, Tomi S Mikkola, Esko Kankuri, Orlando J Rojas

Abstract read
In one paragraph

Article in ACS polymers Au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Designing for Degradation: Transient Devices Enabled by (Nano)Cellulose.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  4. Review
  5. ComparativeBiomacromolecules · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rubina AjdaryDepartment of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, PO Box 16300, FI-00076 Aalto, Espoo, Finland.
Guillermo ReyesDepartment of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, PO Box 16300, FI-00076 Aalto, Espoo, Finland.ORCID https://orcid.org/0000-0002-3468-1137
Jani KuulaDepartment of Neuroscience and Biomedical Engineering, School of Science, Aalto University, PO Box 16300, FI-00076 Aalto, Espoo, Finland.
Eija Raussi-LehtoDepartment of Neuroscience and Biomedical Engineering, School of Science, Aalto University, PO Box 16300, FI-00076 Aalto, Espoo, Finland.
Tomi S MikkolaDepartment of Obstetrics and Gynecology, University of Helsinki, and Helsinki University Hospital, 00290 Helsinki, Finland.
Esko KankuriDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland.ORCID https://orcid.org/0000-0002-2193-8773
Orlando J RojasDepartment of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, PO Box 16300, FI-00076 Aalto, Espoo, Finland.ORCID https://orcid.org/0000-0003-4036-4020

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Direct ink writing via single or multihead extrusion is used to synthesize layer-by-layer (LbL) meshes comprising renewable polysaccharides. The best mechanical performance (683 ± 63 MPa modulus and 2.5 ± 0.4 MPa tensile strength) is observed for 3D printed structures with full infill density, given the role of electrostatic complexation between the oppositely charged components (chitosan and cellulose nanofibrils). The LbL structures develop an unexpectedly high wet stability that undergoes gradual weight loss at neutral and slightly acidic pH. The excellent biocompatibility and noncytotoxicity toward human monocyte/macrophages and controllable shrinkage upon solvent exchange make the cellular meshes appropriate for use as biomedical implants.

Identifiers

PMID35445214
PMCPMC9011395

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.