Evidence map›Paper›PMID 35445200›Full record

ArticleJournal of surgery and research2022

Post-Operative Atrial Fibrillation: Current Treatments and Etiologies for a Persistent Surgical Complication.

Leilani A Lopes, Devendra K Agrawal

2 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in Journal of surgery and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05966857 nacompletednot on this mapstarted 2023, after this paper: background citation

FAPO-X: Assisted Digital Telemonitoring With Wearables in Patients After Cardiovascular Surgery

TypeinterventionalSponsorUniversity of Sao PauloRan2023 to 2023Enrolled108ConditionsHeart, Surgery, Heart, Functional Disturbance as ResultArmsWearable: Smartwatch
NCT06958029 recruitingnot on this mapstarted 2025, after this paper: background citation

Incidence and Risk Factors of Postoperative Atrial Fibrillation in Cardiac Surgery Patients

TypeobservationalSponsorKhon Kaen UniversityRan2025 to 2025Enrolled275ConditionsPost-operative Atrial FibrillationArmsCardiac surgery
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. The Value of Left Atrial Strain and Strain Rate for Prediction of Early Postoperative Atrial Fibrillation Following Isolated Off-Pump Coronary Artery Bypass Grafting in Low-Risk Patients.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
    Article
  6. Article
  7. Limitations of Current Therapies and Barriers in Alzheimer's Disease.Archives of internal medicine research · 2026
    Article
  8. Impact of new-onset atrial fibrillation on 12-month outcomes and mortality after esophagectomy.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. The Role of the CHAPakistan journal of medical sciences · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Leilani A LopesWestern University of Health Sciences, College of Osteopathic Medicine of the Pacific - Northwest, Lebanon, OR, USA.
Devendra K AgrawalWestern University of Health Sciences, College of Osteopathic Medicine of the Pacific, Pomona, CA, USA.
Western University of Health Sciences · US

Funding

Novel Approach to Stabilize Atherosclerotic Plaque in Carotid ArteryR01HL144125 · NHLBI · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI AGRAWAL, DEVENDRA K. · 2018 to 2021
$2.8M
Novel Molecular Target to Prevent Maturation Failure of Arteriovenous FistulaR01HL147662 · NHLBI · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI AGRAWAL, DEVENDRA K. · 2019 to 2022
$2.8M
NHLBI NIH HHS R01 HL144125NHLBI NIH HHS R01 HL147662
6 · The paper itself

Abstract

Post-operative atrial fibrillation (POAF) is a persistent and serious surgical complication that occur in 20-55% of cardiac surgery cases. POAF may lead to adverse health outcomes such as stroke, thromboembolism, cardiac arrest, and mortality, and may develop long-term. Patients have a 2-fold increase in mortality risk and spend about 3.7 more days in the hospital and $16,000 more in medical costs during their visit. The mechanisms and risk factors of POAF are still poorly understood, yet a strong foundation of how a disease process occurs is needed to provide the most effective treatment. Current mechanisms that are postulated to contribute to POAF include an increase in sympathetic tone, oxidative stress, local and systemic inflammation, a trigger that induces atrial substrate changes, a driver to sustain POAF, and electrolyte disturbances such as hypomagnesemia. While needing more research, current risk factors include age, male sex, history of myocardial infarction or heart failure, hypertension, diabetes, obesity, and COPD. Treatments mostly include prophylaxis of repurposed drugs such as beta-blockers, statins, oral anticoagulants, antiarrhythmics, and Vitamin D and electrolyte supplementation. Autonomic denervation has also been a promising preventative measure for patients undergoing cardiac surgery. This critical review article provides an up-to-date and comprehensive summary of the pathophysiology of POAF, current clinical risk factors and management for POAF and discusses new pathways for further investigation.

Indexed as

Atrial fibrillationCardiac surgeryInflammationOxidative damagePOAFPost-operative atrial fibrillation

Identifiers

PMID35445200
PMCPMC9017863
OpenAlexW4225833430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.