Evidence map›Paper›PMID 35445192›Full record

ArticleBrain communications2022

α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor and RNA processing gene dysregulation are early determinants of selective motor neuron vulnerability in a mouse model of amyotrophic lateral sclerosis.

Pardis F Zanganeh, Samantha K Barton, Katherine Lim, Elizabeth L Qian, Duncan E Crombie, Christopher R Bye, Bradley J Turner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Pardis F ZanganehThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3052, Australia.
Samantha K BartonThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3052, Australia.ORCID https://orcid.org/0000-0001-7601-0238
Katherine LimThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3052, Australia.
Elizabeth L QianThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3052, Australia.
Duncan E CrombieThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3052, Australia.
Christopher R ByeThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3052, Australia.
Bradley J TurnerThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3052, Australia.ORCID https://orcid.org/0000-0001-6580-7655
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis is a late-onset adult neurodegenerative disease, although there is mounting electrophysiological and pathological evidence from patients and animal models for a protracted preclinical period of motor neuron susceptibility and dysfunction, long before clinical diagnosis. The key molecular mechanisms linked to motor neuron vulnerability in amyotrophic lateral sclerosis have been extensively studied using transcriptional profiling in motor neurons isolated from adult mutant superoxide dismutase 1 mice. However, neonatal and embryonic motor neurons from mutant superoxide dismutase 1 mice show abnormal morphology and hyperexcitability, suggesting preceding transcriptional dysregulation. Here, we used RNA sequencing on motor neurons isolated from embryonic superoxide dismutase 1

Indexed as

AMPA receptoramyotrophic lateral sclerosismotor neuronsRNA processingtranscriptomics

Identifiers

PMID35445192
PMCPMC9016138
OpenAlexW4226063928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.