Evidence map›Paper›PMID 35445005›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Droplet-Microfluidic-Based Promoter Engineering and Expression Fine-Tuning for Improved Erythromycin Production in

Kaiyue Yun, Yue Zhang, Shixin Li, Yan Wang, Ran Tu, Hao Liu, Meng Wang

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Heterologous production of epothilones inSynthetic and systems biotechnology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. CRISPR/Cas9-Mediated Promoter Engineering in Saccharopolyspora erythraea.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kaiyue YunCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Yue ZhangKey Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Shixin LiCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Yan WangCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Ran TuKey Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Hao LiuCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Meng WangKey Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erythromycin is a clinically important drug produced by the rare actinomycete

Indexed as

droplet-based microfluidicserythromycingene overexpressionhigh-throughput screeningproduction improvementpromoter engineeringSaccharopolyspora erythraea

Identifiers

PMID35445005
PMCPMC9013967

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.