Evidence map›Paper›PMID 35445000›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Derivation of Stem Cell-like Cells From Spherical Culture of Astrocytes for Enhanced Neural Repair After Middle Cerebral Artery Occlusion.

Dan Zhu, Zheming Cao, Xiaoyang Pang, Wei Jiang, Chihao Li, Xing Zhang, Xibin Tian, Haijun Tu, Panfeng Wu, Hemin Nie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Astrocytes promote oligodendrocyte precursor cell proliferation via Cx47Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Dan ZhuDepartment of Biomedical Sciences, College of Biology, Hunan University, Changsha, China.
Zheming CaoDepartment of Orthopedics, Xiangya Hospital Central South University, Changsha, China.
Xiaoyang PangDepartment of Orthopedics, Xiangya Hospital Central South University, Changsha, China.
Wei JiangDepartment of Pharmaceutics, College of Biology, Hunan University, Changsha, China.
Chihao LiDepartment of Biomedical Sciences, College of Biology, Hunan University, Changsha, China.
Xing ZhangDepartment of Orthopedics, Xiangya Hospital Central South University, Changsha, China.
Xibin TianDepartment of Pharmaceutics, College of Biology, Hunan University, Changsha, China.
Haijun TuDepartment of Pharmaceutics, College of Biology, Hunan University, Changsha, China.
Panfeng WuDepartment of Orthopedics, Xiangya Hospital Central South University, Changsha, China.
Hemin NieDepartment of Biomedical Sciences, College of Biology, Hunan University, Changsha, China.
Hunan University · CNCentral South University · CNXiangya Hospital Central South University · CN

Funding

FACTORS THAT MODIFY INSULIN ACTIONR01DK002001 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BUSE, MARIA G · 1986 to 2012
$3.1M
Factors that modify insulin actionR56DK002001 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BUSE, MARIA G · 2008 to 2008
$199k
NIDDK NIH HHS R01 DK002001NIDDK NIH HHS R56 DK002001
6 · The paper itself

Abstract

Neural precursor cells (NPCs) tend to aggregate and develop into three-dimensional (3D) spheres, which in turn help maintain the stemness of the cells. This close relationship between spherical environments and cell stemness direct us to assume that 3D spheres of astrocytes (ASTs) may facilitate the acquisition of stem cell-like features and generate sufficient seed cells for the regeneration of neurons.

Indexed as

astrocytecell transplantationneural differentiationneural stem celltissue regeneration

Identifiers

PMID35445000
PMCPMC9013960
OpenAlexW4226435665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.