Evidence map›Paper›PMID 35444774›Full record

ArticleMediterranean journal of hematology and infectious diseases2022

TdT Positive Lymphoma with MYC, BCL2 and BCL6 Rearrangements: A Review of Diagnosis and Treatment.

Aditi Singh, Ishaq Asghar, Laura Kohler, Daniel Snower, Hosam Hakim, Daniel Lebovic

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PubMed Full text at PMC Publisher
In one paragraph

Article in Mediterranean journal of hematology and infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aditi SinghDepartment of Hematology and Oncology, Ascension St. John Hospital.
Ishaq AsgharDepartment of Pathology, Ascension St. John Hospital.
Laura KohlerDepartment of Hematology and Oncology, Ascension St. John Hospital.
Daniel SnowerDepartment of Pathology, Ascension St. John Hospital.
Hosam HakimDepartment of Hematology and Oncology, Ascension St. John Hospital.
Daniel LebovicDepartment of Hematology and Oncology, Ascension St. John Hospital.
Ascension · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the modern era, classification of neoplasms not only depends on immunomorphological features but also on specific disease-defining genetic events. Translocations/rearrangements of MYC/8q24 locus combined with BCL-2 or BCL6 translocations (double/triple hit) are considered hallmarks of high-grade B-cell lymphoma (HGBL), a type of aggressive mature B-cell lymphoma. When cases with immature immunophenotypes present these rearrangements, diagnosis becomes very difficult. We herein report an unusual case of an aggressive B-cell lymphoma/leukemia that presented with immature morphology and immunophenotype with triple hit gene rearrangements. This case highlights the difficulty in classifying and appropriately treating these patients. The novel aspect is the treatment and outcome with chimeric antigen receptor or

Indexed as

CAR T-cell therapyDiffuse Large B-cell LymphomaDouble/triple hit lymphomaLeukemiaLymphomaTerminal deoxynucleotidyl transferase

Identifiers

PMID35444774
PMCPMC8992619
OpenAlexW4214544079

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.