ArticleObstetric medicine2022
Childhood adversity, prenatal depression, and maternal inflammation across pregnancy.
Article in Obstetric medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Childhood abuse and perinatal outcomes for mother and child: A systematic review of the literature.PloS one · 2024Pooled it
- Associations Between Adverse Childhood Experiences and Prenatal Depression Mediated Through Family Communication in Chinese Pregnant Women: Causal Mediation Analysis.Depression and anxiety · 2026Article
- The role of perinatal perceived stress in the setting of adverse childhood experience and perinatal anxiety and depressive symptoms.BMC psychology · 2025Article
- Coordination of inflammatory and adrenocortical stress response during pregnancy and variation by mental health.Brain, behavior, & immunity - health · 2025Article
- A Brief Historic Review of Research on Early Life Stress and Inflammation across the Lifespan.Neuroimmunomodulation · 2025Review
- Longitudinal course of endocannabinoids andPsychological medicine · 2023Article
- Is There an Inflammatory Profile of Perinatal Depression?Current psychiatry reports · 2023Review
- Neutrophil-to-lymphocyte ratio (NLR) variations in relationship with childhood maltreatment in patients with anorexia nervosa: a retrospective cohort study.Eating and weight disorders : EWD · 2022Article
- Exposure to childhood maltreatment and systemic inflammation across pregnancy: The moderating role of depressive symptomatology.Brain, behavior, and immunity · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Background: To examine whether change in neutrophil-lymphocyte ratio, a marker of systemic inflammation, differs by childhood adversity and prenatal depression. Methods: Prenatal complete blood count data were used to calculate neutrophil-lymphocyte ratio in first and third trimesters. The Adverse Childhood Experiences scale measured childhood adversity, and the Patient Health Questionnaire-9 measured depression. This is a secondary analysis of a study of predictors of risk for sleep-disordered breathing. Results: Participants were 98 pregnant women, mean age 30 years ( Conclusion: Experiences of sexual abuse in childhood may impact markers of systemic inflammation in pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.