ReviewClinical practice and epidemiology in mental health : CP & EMH2021
Clinical Implications of Cancer Related Inflammation and Depression: A Critical Review.
Review in Clinical practice and epidemiology in mental health : CP & EMH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Using eHealth to Support Quality of Life and Well-Being in Patients With Lung Cancer: Systematic Review.JMIR cancer · 2025Pooled it
- Pooled it
- Guideline
- Psychobiotics Ameliorate Depression and Anxiety Status in Surgical Oncology Patients: Results from theNutrients · 2025Trial
- Prevalence and Associated Risk Factors of Psychiatric Comorbidities Among the Hospitalized Patients in Bangladesh: A Cross-Sectional Study.Health science reports · 2026Article
- Psychological impact of hospital admission in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Article
- Efficacy and Safety of Electroacupuncture for Postoperative Insomnia in Patients With Spinal Metastasis: Protocol of a Prospective, Multicenter, Randomized Controlled Study.JMIR research protocols · 2026Article
- Factors associated with depression among people with cancer: Systematic umbrella review.Palliative & supportive care · 2026Review
- Pharmacotherapeutic Management of Depression in Patients With Cancer: A Review of Mechanistic and Clinical Evidence.Cancer reports (Hoboken, N.J.) · 2026Review
- Effect of an integrated mHealth supportive care program on symptom burden and self-efficacy in post-treatment breast cancer survivors: a randomized controlled trial.Journal of cancer survivorship : research and practice · 2026Article
- Interleukin-6, anxiety, and pre-treatment malnutrition in locally advanced head and neck cancer: a psychoneuroimmunological analysis.Frontiers in nutrition · 2026Article
- Psychiatric Comorbidity, Functional Status, and Neuroinflammatory Pathways in Cancer Patients with and Without Type 2 Diabetes.Diseases (Basel, Switzerland) · 2025Article
- Core preoperative symptoms and patients' symptom experiences in oral cancer: a mixed-methods study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Physical Activity and Depression in Breast Cancer Patients: Mechanisms and Therapeutic Potential.Current oncology (Toronto, Ont.) · 2025Review
- Distress and inflammation are independently associated with cancer-related symptom severity.Comprehensive psychoneuroendocrinology · 2024Article
- Associations of inflammation with neuropsychological symptom cluster in patients with Head and neck cancer: A longitudinal study.Brain, behavior, & immunity - health · 2023Article
- An Overview of the International Literature on Health-Related Quality of Life, Mental Health and Psychosocial Issues in People with Cancer.Clinical practice and epidemiology in mental health : CP & EMH · 2021Article
- The role of baseline and persistent depression in adjuvant cancer therapy: impact on toxicity and quality of life.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuropsychiatric symptoms are problematic in cancer settings. In addition to poor quality of life, depression is associated with worsened survival. Patients who develop depression that responds to treatment have the same cancer-related survival as those patients who never had depression. Although depression in patients with cancer is common, it is often unrecognized, untreated, or at best, undertreated. There remains untapped potential for underlying cancer-related biology associated with depression to help clinicians correctly identify depressed cancer patients and orchestrate appropriate treatments to address cancer-related depression. Biologically, inflammation has been most vigorously described in its association with depression in otherwise healthy patients and to a significant extent in patients with medical illness. This association is especially relevant to patients with cancer since so many aspects of cancer induce inflammation. In addition to cancer itself, its treatments (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.