ArticleFrontiers in endocrinology2022
The Role of Urinary Extracellular Vesicles Sodium Chloride Cotransporter in Subtyping Primary Aldosteronism.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Emerging methods for subtype differentiation in primary aldosteronism.Journal of internal medicine · 2026Review
- Advances in the biochemical diagnostics of primary aldosteronism: from immunoassays to steroidomics and proteomics.Frontiers in endocrinology · 2025Review
- Sodium Chloride Cotransporter in Hypertension.Biomedicines · 2024Review
- Urinary extracellular vesicles carry valuable hints through mRNA for the understanding of endocrine hypertension.Frontiers in endocrinology · 2023Article
- Diabetes with kidney injury may change the abundance and cargo of urinary extracellular vesicles.Frontiers in endocrinology · 2023Article
- Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter.Frontiers in endocrinology · 2022Review
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Adrenal venous sampling (AVS) is recognized as the gold standard for subtyping primary aldosteronism (PA), but its invasive nature and technical challenges limit its availability. A recent study reported that sodium chloride cotransporter (NCC) in urinary extracellular vesicles (uEVs) is a promising marker for assessing the biological activity of aldosterone and can be treated as a potential biomarker of PA. The current study was conducted to verify the hypothesis that the expression of NCC and its phosphorylated form (pNCC) in uEVs are different in various subtypes and genotypes of PA and can be used to select AVS candidates. Methods: A total of 50 patients with PA were enrolled in the study. Urinary extracellular vesicles (uEVs) were isolated from spot urine samples using ultracentrifugation. NCC and pNCC expressions were tested in patients diagnosed with PA who underwent AVS. Sanger sequencing of Results: pNCC (1.89 folds, Conclusions: The expression of pNCC in uEVs in patients with PA with various subtypes and genotypes was different. It can be used as biomarker of AVS for PA subtyping.
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