ArticleFrontiers in psychiatry2022
Increased Prefrontal Activation During Verbal Fluency Task After Repetitive Transcranial Magnetic Stimulation Treatment in Depression: A Functional Near-Infrared Spectroscopy Study.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- The Immediate and sustained benefits of two-week high-frequency aerobic exercise on depressive symptoms and frontal function in subthreshold depression: A randomized controlled trial.Translational psychiatry · 2026Trial
- Quantitative mapping of prefrontal oxygenation dysfunction and neuropsychiatric symptoms in patients with systemic lupus erythematosus: a multichannel functional near-infrared spectroscopy study.Lupus science & medicine · 2026Article
- Utility of Functional Near-infrared Spectroscopy (fNIRS) in Major Depressive Disorder: A Systematic Review.Indian journal of psychological medicine · 2026Review
- fNIRS reveals comparable reductions in cortical hyperconnectivity following once-daily and twice-daily rTMS in poststroke aphasia.Biomedical optics express · 2026Article
- Reduced left dorsolateral prefrontal activation and right inferior frontal de-oxygenation differ between psychotic and non-psychotic adolescent depression during verbal fluency.Frontiers in psychiatry · 2026Article
- Application of functional near-infrared spectroscopy in evaluating antidepressant treatment efficacy: a review of recent evidence (2021-2026).Frontiers in psychology · 2026Review
- Reduced intra-frontal functional connectivity during a verbal fluency task in depressed individuals with autistic traits: an fNIRS study.Frontiers in human neuroscience · 2026Article
- Differences in Prefrontal Cortex Activation Between Predominantly Positive and Negative Symptom Profiles in Schizophrenia: A Functional Near-Infrared Spectroscopy Study.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Clinical development and guiding theory of transcranial magnetic stimulation: a literature review.Annals of medicine · 2025Review
- Cortical activation and functional connectivity during verbal fluency task in patients with chronic insomnia: a multi-channel fNIRS study.Scientific reports · 2025Article
- Applications of Functional Near-Infrared Spectroscopy (fNIRS) in Monitoring Treatment Response in Psychiatry: A Scoping Review.Journal of clinical medicine · 2025Review
- Unveiling Cognitive Interference: fNIRS Insights Into Poststroke Aphasia During Stroop Tasks.Neural plasticity · 2025Article
- fNIRS evidence of abnormal frontotemporal cortex activation and functional connectivity in depressed patients after stroke: neuromodulatory mechanisms from mild to moderate depression.Frontiers in neurology · 2025Article
- Multidimensional analysis of brain activation patterns in different motor therapies using functional near-infrared spectroscopy.Frontiers in neurology · 2025Article
- Study on the Changes of Brain Function in Adolescents With Pain-Depression Comorbidity Based on rs-FMRI.Depression and anxiety · 2025Article
- Characteristic Changes of Prefrontal and Motor Areas in Patients with Type 2 Diabetes and Major Depressive Disorder During a Motor Task of Tai Chi Chuan: A Functional Near-Infrared Spectroscopy Study.Brain and behavior · 2024Article
- Distinction of mental health between salesman and R&D in high-tech enterprise: a fNIRS study.Scientific reports · 2024Article
- Functional near-infrared spectroscopy-based diagnosis support system for distinguishing between mild and severe depression using machine learning approaches.Neurophotonics · 2024Article
- Efficacy and executive function of solution-focused brief therapy on adolescent depression.Frontiers in psychiatry · 2024Article
- Intermittent theta burst stimulation for negative symptoms in schizophrenia patients with mild cognitive impairment: a randomized controlled trail.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Previous studies have shown the clinical effect of 2 Hz repetitive transcranial magnetic stimulation (rTMS) for depression; however, its underlying neural mechanisms are poorly understood. The aim of this study was to examine the effects of rTMS on the activity of the prefrontal cortex in patients with depression, using functional near-infrared spectroscopy (fNIRS). Methods: Forty patients with major depressive disorder (MDD) and 40 healthy controls were enrolled in this study. Patients underwent 4 weeks of 2 Hz TMS delivered to the right dorsolateral prefrontal cortex (DLPFC). fNIRS was used to measure the changes in the concentration of oxygenated hemoglobin ([oxy-Hb]) in the prefrontal cortex during a verbal fluency task (VFT) in depressed patients before and after rTMS treatment. The severity of depression was assessed using the Hamilton Rating Scale for Depression-24 item (HAMD-24). Results: Prior to rTMS, depressed patients exhibited significantly smaller [oxy-Hb] values in the bilateral prefrontal cortex during the VFT compared with the healthy controls. After 4 weeks of 2 Hz right DLPFC rTMS treatment, increased [oxy-Hb] values in the bilateral frontopolar prefrontal cortex (FPPFC), ventrolateral prefrontal cortex (VLPFC) and left DLPFC during the VFT were observed in depressed patients. The increased [oxy-Hb] values from baseline to post-treatment in the right VLPFC in depressed patients were positively related to the reduction of HAMD score following rTMS. Conclusion: These findings suggest that the function of the prefrontal cortex in depressed patients was impaired and could be recovered by 2 Hz rTMS. The fNIRS-measured prefrontal activation during a cognitive task is a potential biomarker for monitoring depressed patients' treatment response to rTMS.
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