ArticleFrontiers in aging neuroscience2022
Degeneration of the Sensorimotor Tract in Degenerative Cervical Myelopathy and Compensatory Structural Changes in the Brain.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Beyond the aging spine - a systematic review of functional changes in the human brain in cervical spondylotic myelopathy.GeroScience · 2024Pooled it
- Abnormalities of brain structure and function in cervical spondylosis: a multi-modal voxel-based meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Characterizing proprioceptive dysfunction as an early sensory indicator of mild Degenerative Cervical Myelopathy.North American Spine Society journal · 2026Article
- Spinal cord diffusion tensor imaging predicts balance in degenerative cervical myelopathy.Frontiers in neuroscience · 2026Article
- Functional and structural brain remodeling in patients with degenerative cervical myelopathy following cervical decompression surgery.Communications medicine · 2025Article
- Predictive Value of Preoperative Short Form-36 Survey Scale for Postoperative Axial Neck Pain in Patients With Degenerative Cervical Myelopathy.Global spine journal · 2025Article
- Systematic investigation of cerebellar functional alterations and their association with surgical outcomes in patients with degenerative cervical myelopathy: a resting-state fMRI study.La Radiologia medica · 2024Article
- Investigation of perfusion impairment in degenerative cervical myelopathy beyond the site of cord compression.Scientific reports · 2023Article
- Remodeling of the brain correlates with gait instability in cervical spondylotic myelopathy.Frontiers in neuroscience · 2023Article
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13 authors.
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Abstract
Degenerative cervical myelopathy is a progressive neurodegenerative disease, that has become increasingly prevalent in the aging population worldwide. The current study determined the factors affecting degeneration in the sensorimotor tract with degenerative cervical myelopathy and its relationship with brain structure. We divided patients into hyperintensity (HS) and non-hyperintensity (nHS) groups and measured the fractional anisotropy and apparent diffusion coefficients of the lateral corticospinal tract (CST), fasciculus gracilis and fasciculus cuneatus (FGC). Voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) techniques were used to estimate brain structure changes. Correlation of the modified Japanese Orthopaedic Association (mJOA) score, light touch, pinprick, motor score, and fractional anisotropy (FA) ratios of the CST at different levels were analyzed. Compared to healthy controls, the FA ratios of CST in the HS and nHS groups were decreased at all levels, and the apparent diffusion coefficient (ADC) ratio was increased only at C4/5 levels in the HS group. The FA ratio of FGC was decreased at the C3/4 and C4/5 levels in the HS group and only decreased at the C4/5 level in the nHS group. The ADC ratio was decreased only at the C4/5 level in the HS group. VBM analysis revealed that the volume of the precentral gyrus, postcentral gyrus, and paracentral lobule increased in patients compared to controls. TBSS analysis found no statistical significance between the sensory and motor tracts in white matter. The volume of clusters in HS and nHS groups negatively correlated with the C1/2 FA ratio of the CST. The results showed that the degeneration distance of the CST was longer than the FGC, and the degeneration distance was related to the degree of compression and spinal cord damage. Structural compensation and the neurotrophin family may lead to enlargement of the brain.
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