Evidence map›Paper›PMID 35444526›Full record

ArticleFrontiers in aging neuroscience2022

Cortical Thickness Changes After Computerized Working Memory Training in Patients With Mild Cognitive Impairment.

Haakon R Hol, Marianne M Flak, Linda Chang, Gro Christine Christensen Løhaugen, Knut Jørgen Bjuland, Lars M Rimol, Andreas Engvig, Jon Skranes, Thomas Ernst, Bengt-Ove Madsen and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05948930 (Adaptive Working Memory and Physical Exercise Training to Improve Brain and Mitochondrial Function in MCI), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05948930 narecruitingnot on this mapstarted 2024, after this paper: background citation

Adaptive Working Memory and Physical Exercise Training to Improve Brain and Mitochondrial Function in MCI

TypeinterventionalSponsorUniversity of Maryland, BaltimoreRan2024 to 2027Enrolled90ConditionsMild Cognitive ImpairmentArmsProgressive aerobic exercise, Adaptive cognitive training, Combined
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haakon R HolDepartment of Radiology, Sørlandet Hospital, Arendal, Norway.
Marianne M FlakDepartment of Pediatrics, Sørlandet Hospital, Arendal, Norway.
Linda ChangDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
Gro Christine Christensen LøhaugenDepartment of Pediatrics, Sørlandet Hospital, Arendal, Norway.
Knut Jørgen BjulandDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Lars M RimolDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Andreas EngvigDepartment of Medicine, Diakonhjemmet Hospital, Oslo, Norway.
Jon SkranesDepartment of Pediatrics, Sørlandet Hospital, Arendal, Norway.
Thomas ErnstDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
Bengt-Ove MadsenDepartment of Geriatric and Internal Medicine, Sørlandet Hospital, Arendal, Norway.
Susanne S HernesDepartment of Clinical Science, University of Bergen, Bergen, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Adaptive computerized working memory (WM) training has shown favorable effects on cerebral cortical thickness as compared to non-adaptive training in healthy individuals. However, knowledge of WM training-related morphological changes in mild cognitive impairment (MCI) is limited. Objective: The primary objective of this double-blind randomized study was to investigate differences in longitudinal cortical thickness trajectories after adaptive and non-adaptive WM training in patients with MCI. We also investigated the genotype effects on cortical thickness trajectories after WM training combining these two training groups using longitudinal structural magnetic resonance imaging (MRI) analysis in Freesurfer. Method: Magnetic resonance imaging acquisition at 1.5 T were performed at baseline, and after four- and 16-weeks post training. A total of 81 individuals with MCI accepted invitations to undergo 25 training sessions over 5 weeks. Longitudinal Linear Mixed effect models investigated the effect of adaptive vs. non-adaptive WM training. The LME model was fitted for each location (vertex). On all statistical analyzes, a threshold was applied to yield an expected false discovery rate (FDR) of 5%. A secondary LME model investigated the effects of Results: A total of 62 participants/patients completed the 25 training sessions. Structural MRI showed no group difference between the two training regimes in our MCI patients, contrary to previous reports in cognitively healthy adults. No significant structural cortical changes were found after training, regardless of training type, across all participants. However, Conclusion: The MCI patients in our study, did not have improved cortical thickness after WM training with either adaptive or non-adaptive training. These results were derived from a heterogeneous population of MCI participants. The lack of changes in the cortical thickness trajectory after WM training may also suggest the lack of atrophy during this follow-up period. Our promising results of increased cortical thickness trajectory, suggesting greater neuroplasticity, in those with

Indexed as

APOE genotypecortical thicknessLMX1AMCIworking memory training

Identifiers

PMID35444526
PMCPMC9014119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.