Evidence map›Paper›PMID 35444450›Full record

ArticleJournal of inflammation research2022

Expression of Human Interleukin 8 in Mice Alters Their Natural Behaviors.

Zuozhen Tian, Frances S Shofer, Alec Z Sandroni, Lan Zhao, Carla R Scanzello, Yejia Zhang

Open access · goldAbstract read
In one paragraph

Article in Journal of inflammation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Interleukin-8 in health and disease.Molecular biomedicine · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Zuozhen TianDepartment of Physical Medicine & Rehabilitation, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Frances S ShoferDepartment of Physical Medicine & Rehabilitation, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Alec Z SandroniDepartment of Physical Medicine & Rehabilitation, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Lan ZhaoDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA.
Carla R ScanzelloDivision of Rheumatology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yejia ZhangDepartment of Physical Medicine & Rehabilitation, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-7484-8800
Hospital of the University of Pennsylvania · USRush University Medical Center · USUniversity of Pennsylvania · US

Funding

Modulation of Inflammation in Osteoarthritis via CD14-mediated pattern recognitionR01AR075737 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Carla Rose Scanzello · 2020 to 2026
$2.8M
Inhibition of TNF-alpha Signaling to Reduce Intervertebral Disc InflammationR21AR078386 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI ZHANG, YEJIA · 2021 to 2022
$383k
ADAM8 in Intervertebral Disc DegenerationR21AR071623 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI ZHANG, YEJIA · 2018 to 2019
$364k
NIAMS NIH HHS R01 AR075737NIAMS NIH HHS R21 AR071623NIAMS NIH HHS R21 AR078386
6 · The paper itself

Abstract

Objective: To examine the effects of human interleukin (IL) 8 expression on mouse behavior. Methods: A mouse line expressing human IL8 in the intervertebral discs (IVD) and cartilaginous tissues ( Results: Distance traveled by the Conclusion: The

Indexed as

agebehaviordeclineinterleukin (IL) 8mouse

Identifiers

PMID35444450
PMCPMC9013918
OpenAlexW4223495716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.