ReviewJournal of inflammation research2022
New Insights in the Treatment of SAPHO Syndrome and Medication Recommendations.
Review in Journal of inflammation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- How Organ Manifestations Beyond the Bone May Guide Risk Stratification and Treatment Decisions in Chronic Nonbacterial Osteomyelitis.Paediatric drugs · 2026Review
- Juvenile-Onset SAPHO Syndrome With Acne-Hidradenitis Suppurativa Successfully Treated With Infliximab and Methotrexate.The Journal of dermatology · 2026Article
- Case Report: Successful Treatment With Apremilast of SAPHO Syndrome and Refractory Pain.International journal of rheumatic diseases · 2026Article
- CT and MRI features of SAPHO syndrome: a report of 6 cases.BMC musculoskeletal disorders · 2026Article
- Prolonged remission of SAPHO syndrome with low-dose leflunomide: A case report and literature review.Experimental and therapeutic medicine · 2026Article
- Physicians' perspectives on the diagnosis and treatment of adult SAPHO syndrome: a cross-sectional study from China.Clinical rheumatology · 2026Article
- SAPHO syndrome and pustular skin diseases: shared inflammatory circuits, divergent tissue outcomes, and the limits of a spectrum model.Frontiers in immunology · 2026Review
- Case Report: Rapid improvement with upadacitinib in a case of paradoxical skin lesions associated with SAPHO syndrome.Frontiers in immunology · 2026Article
- Case Report: Successful treatment of SAPHO syndrome refractory to adalimumab with upadacitinib.Frontiers in immunology · 2026Article
- Wilforine attenuates inflammatory osteolysis by suppressing osteoclast fusion through JAK-STAT-stomatin immunoregulatory signaling.Frontiers in immunology · 2026Article
- Chronic nonbacterial osteomyelitis: a typical case and review.Frontiers in pediatrics · 2026Review
- JAK Inhibitors for Treatment of SAPHO Syndrome: A Systematic Review of 72 Cases.ACR open rheumatology · 2025Review
- Synovitis, acne, pustular lesions, hyperostosis, and osteitis syndrome associated with monoclonal gammopathy of undetermined significance: a case report.BMC musculoskeletal disorders · 2025Article
- Investigating the Efficacy Variability of Different JAK Inhibitors in Chronic Nonbacterial Osteitis (CNO) Presenting Primarily With Pyoderma Gangrenosum.International journal of rheumatic diseases · 2025Article
- Therapeutic approaches for SAPHO syndrome from the perspective of pathogenesis: a review of the literature.Frontiers in immunology · 2025Review
- Awareness of the Risk of Paradoxical Psoriasis in Patients with SAPHO Syndrome Undergoing Treatment with Secukinumab: A Case Series.Journal of inflammation research · 2025Article
- SAPHO syndrome complicated by IgG4-related ophthalmic disease: a case report and literature review.Frontiers in immunology · 2025Review
- Case Report: Successful treatment of refractory synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome and palmoplantar pustulosis with ustekinumab.Frontiers in immunology · 2025Article
- The effects on clinical characteristics, potential factors and outcomes in SAPHO patients during the COVID-19 epidemic.Frontiers in medicine · 2025Article
- A Case of Isolated Extramedullary Plasmacytoma of the Sternoclavicular joint: A Rare Case Report.Journal of inflammation research · 2025Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome is a rare autoinflammatory disease characterized by dermatological disorders and osteoarticular inflammatory lesions. This article reviews the application of biologics and other treatments based on the therapeutic target and the size of molecules in SAPHO syndrome. We found that drugs, especially biologics, have different effects on bone, joint, and skin damage. This may relate to the different inflammatory pathways involved in the osteoarticular and cutaneous symptoms in SAPHO patients. In this study, we provide stratified medication recommendations for SAPHO syndrome. Patients with osteoarticular symptoms can consider tumor necrosis factor blockers, JAK inhibitor, interleukin (IL)-1 inhibitor, and IL-17 inhibitor. Patients with cutaneous symptoms should consider IL-17 and JAK inhibitors. Apremilast, Tripterygium wilfordii Hook F, and bisphosphonates are other effective treatments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.