ArticlePatient preference and adherence2022
Improving Medication Adherence in Community-Dwelling Patients with Schizophrenia Through Therapeutic Alliance and Medication Attitude: A Serial Multiple Mediation Model.
Article in Patient preference and adherence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Impact of Interventions on Medication Adherence in Patients With Coexisting Diabetes and Hypertension.Health expectations : an international journal of public participation in health care and health policy · 2024Pooled it
- Medication Adherence, Treatment Attitudes, and Beliefs About Medicines in Romanian Psychiatric Patients: A Cross-Sectional Study.Diseases (Basel, Switzerland) · 2026Article
- Acceptance of mental illness and attitude towards pharmacotherapy among patients hospitalized in forensic psychiatry departments.Frontiers in psychiatry · 2026Article
- Latent profile analysis for medication adherence in patients with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2025Article
- Service users' perceptions of relevant and helpful components of an integrated care concept (ACCESS) for psychosis.Frontiers in psychology · 2023Article
- Drug Attitude and Medication Adherence of Patients with Early Psychosis in South Korea: Mediating Effect of Medication Adherence Self-Efficacy.Patient preference and adherence · 2023Article
- [Therapeutic alliance between sectorial psychiatry inpatients and nurses and aides: A prospective, observational and cross-sectional study].Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022Observational
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Increased medication adherence improves patient outcomes and lowers the overall cost of care by preventing disease relapse and hospital readmission. Several systematic reviews have identified that insight, therapeutic alliance, and attitude towards medication affect medication adherence in patients with schizophrenia; however, no study has examined all the aforementioned variables together nor has discussed the chains of these mediators. Purpose: To examine the insight-medication adherence relationship among community-dwelling schizophrenia patients through a serial multiple mediation model of therapeutic alliance and medication attitude. Patients and Methods: This study with a cross-sectional correlational design included a convenience sample of community-dwelling schizophrenia patients from Taiwan (n = 229). From January 2017 to January 2018, data were collected by trained nurses using questionnaires. The PROCESS tool was used to analyse fine-grained chains. Results: In serial multiple mediation, the indirect effect of insight on medication adherence through therapeutic alliance and, subsequently, alteration of medication attitude was significant. However, the direct effect changed from significant to non-significant, indicating a complete mediating effect. Conclusion: In community-dwelling schizophrenia patients, the effects of therapeutic alliance and medication attitude on medication adherence are greater than that of insight. We recommend revising the strategy of community home visits by different psychiatrists or nurses in alternating shifts. Therapeutic alliance is the first step required to promote medication adherence. Based on this alliance, altering the patients' medication attitude may be more effective in improving medication adherence than merely enhancing insight.
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