ArticleNature2022
Somatic genomic changes in single Alzheimer's disease neurons.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 2 pooled it
19.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
140 citing papers in PubMed, 2 syntheses or guidelines pooled it, 213 citations in OpenAlex.
- Preclinical evidence and potential mechanisms of tanshinone ⅡA on cognitive function in animal models of Alzheimer's disease: a systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Hippocampal transcriptome-wide association study and pathway analysis of mitochondrial solute carriers in Alzheimer's disease.Translational psychiatry · 2024Pooled it
- Intranasal drug delivery to the brain for neurodegenerative diseases: Current efforts and challenges in delivery platforms and modeling.Advanced drug delivery reviews · 2026Review
- Pervasive Somatic Mutations inbioRxiv : the preprint server for biology · 2026Article
- Somatic mutations and single-nucleus transcriptomics reveal uniquely human properties of neuronal aging.bioRxiv : the preprint server for biology · 2026Article
- Somatic mosaicism in the brain: linking development, ageing and neurodegeneration.Nature reviews. Neurology · 2026Review
- Oligodendroglial somatic SNCA copy number gains are associated with inclusions and disease onset in multiple system atrophy.Acta neuropathologica · 2026Article
- Article
- Motif-centered analyses reveal universal and tissue-specific mutagenic mechanisms operating in the human body.NAR cancer · 2026Article
- Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Advances in Alzheimer's disease: mechanistic insights and therapeutic targets.Science China. Life sciences · 2026Review
- Somatic mutations and genome mosaicism in aging and disease.Experimental & molecular medicine · 2026Review
- Single-cell transcriptomic atlas of frontoinsular cortex reveals molecular correlates of selective neuronal vulnerability in FTD.bioRxiv : the preprint server for biology · 2026Article
- Article
- Article
- Article
- DREAM repressive activity links somatic mutation, lifespan and disease.Nature aging · 2026Article
- Motif-Centered Analyses Reveal Universal and Tissue-Specific Mutagenic Mechanisms Operating in the Human Body.bioRxiv : the preprint server for biology · 2026Article
- Unravelling genome-wide mosaic microsatellite mutations at single-cell resolution.bioRxiv : the preprint server for biology · 2026Article
- Disease insights from brain somatic mosaicism.Experimental & molecular medicine · 2026Review
80 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 6 institutions in 2 countries.
Michael B Miller *Division of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6205-3314
August Yue Huang *Division of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0416-2854
Junho KimDivision of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.
Zinan ZhouDivision of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.
Samantha L KirkhamDivision of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5444-6636
Eduardo A MauryDivision of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2211-8611
Jennifer S ZiegenfussDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-3828-0381
Hannah C ReedDivision of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.
Jennifer E NeilDivision of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.
Lariza RentoDivision of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9361-441X
Steven C RyuDivision of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0620-9609
Chanthia C MaDivision of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA.
Lovelace J LuquetteDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Heather M AmesDepartment of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5868-7672
Derek H OakleyDepartment of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Matthew P FroschDepartment of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Bradley T HymanDepartment of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7959-9401
Michael A LodatoDivision of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA. michael.lodato@umassmed.edu.ORCID http://orcid.org/0000-0003-4175-1073
Eunjung Alice LeeDivision of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA. ealice.lee@childrens.harvard.edu.
Christopher A WalshDivision of Genetics and Genomics, Manton Center for Orphan Diseases, Boston Children's Hospital, Boston, MA, USA. christopher.walsh@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-0156-2238
Boston Children's Hospital · USBroad Institute · USHarvard University · USAllegheny College · USUniversity of Maryland, Baltimore · USUniversity of Massachusetts Chan Medical School · US
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MResearch Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Sudeshna Das · 2019 to 2026
$36.5MTraining Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8MVASCULAR, PULMONARY AND RENAL INJURYT32HL007627 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GIMBRONE, MICHAEL A, MITCHELL, RICHARD N · 1985 to 2019
$12.7MCell Identity Determination In Human Brain: Somatic Mutation and Cell LineageR01NS032457 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Alice Eunjung Lee, Christopher A. Walsh · 1995 to 2026
$12.7MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4MRates and mechanisms of age-related somatic mutation in normal and Alzheimer brainR01AG070921 · NIA · BOSTON CHILDREN'S HOSPITAL · PI LEE, ALICE EUNJUNG, WALSH, CHRISTOPHER A. · 2021 to 2025
$4.3MMechanism for endogenous retroelements to mimic ancient exogenous identities in aging and diseased human tissueDP2AG072437 · NIA · BOSTON CHILDREN'S HOSPITAL · PI LEE, EUNJUNG ALICE · 2020 to 2020
$2.7MGenome-Wide Somatic Mutation in Alzheimer's Disease Pathogenesis Using Single Neuron AnalysisK08AG065502 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI MILLER, MICHAEL B · 2020 to 2024
$848kSINGLE-CELL ANALYSIS OF SOMATIC MUTATION IN AGING ANO NEUROOEGENERATIVE DISEASE IN THE HUMAN BRAINR00AG054748 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LODATO, MICHAEL ANTHONY · 2019 to 2021
$743kThe role of somatic mutation in neurodegenerative diseaseK01AG051791 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEE, EUNJUNG ALICE · 2016 to 2020
$655kEDUCATION AND TRAINING OF HEALTH SCIENCES LIBRARIANST15LM007098 · NLM · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI SMITH, LINDA C. · 1995 to 1995
–Howard Hughes Medical InstituteNHGRI NIH HHS T32 HG002295NHLBI NIH HHS T32 HL007627NIA NIH HHS DP2 AG072437NIA NIH HHS K01 AG051791NIA NIH HHS K08 AG065502NIA NIH HHS P30 AG062421NIA NIH HHS R00 AG054748NIA NIH HHS R01 AG070921NICHD NIH HHS P50 HD105351NIGMS NIH HHS T32 GM007753NIH HHS T15 LM007098NINDS NIH HHS R01 NS032457
Abstract
Dementia in Alzheimer's disease progresses alongside neurodegeneration
Indexed as
Alzheimer DiseaseNeuronsAgingDNAExonsGenomicsHippocampusHumansMutation RateNucleotidesPrefrontal CortexWhole Genome SequencingDNANucleotides
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.