Evidence map›Paper›PMID 35444279›Full record

ArticleNature2022

Programme of self-reactive innate-like T cell-mediated cancer immunity.

Chun Chou, Xian Zhang, Chirag Krishna, Briana G Nixon, Saida Dadi, Kristelle J Capistrano, Emily R Kansler, Miranda Steele, Jian Han, Amy Shyu and 15 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 103 citations in OpenAlex.

  1. Article
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  8. FcεRγI promotes canine CD8 chimeric antigen receptor T cell cytotoxicity through a Syk-NF-κB axis.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
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  19. Early-life human CD8Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 2 institutions in 1 country.

Chun Chou *Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-7147-4236
Xian Zhang *Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chirag KrishnaComputational Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Briana G NixonImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Saida DadiImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kristelle J CapistranoImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Emily R KanslerImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Miranda SteeleiRepertoire, Huntsville, AL, USA.
Jian HaniRepertoire, Huntsville, AL, USA.
Amy ShyuImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jing ZhangImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Efstathios G StamatiadesImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-2785-9005
Ming LiuImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Shun LiImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mytrang H DoImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chaucie EdwardsImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Davina S KangImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chin-Tung ChenColorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Iris H WeiColorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Emmanouil P PappouColorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Martin R WeiserColorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
J Garcia-AguilarColorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-2451-0948
J Joshua SmithColorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Christina S LeslieComputational Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4571-5910
Ming O LiImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. lim@mskcc.org.ORCID http://orcid.org/0000-0002-1383-0535
Memorial Sloan Kettering Cancer Center · USiRepertoire (United States) · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Ontogeny and Function of Tumor-Resident Innate Lymphocytes and Innate-Like T CellsR01CA243904 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LI, MING · 2020 to 2024
$2.5M
Examining the Role of IRF8 in Tumor-Associated Macrophage Differentiation and FunctionF31CA210332 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI NIXON, BRIANA GLYN · 2017 to 2019
$134k
Howard Hughes Medical InstituteNCI NIH HHS F31 CA210332NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA243904
6 · The paper itself

Abstract

Cellular transformation induces phenotypically diverse populations of tumour-infiltrating T cells

Indexed as

Immunity, InnateInterleukin-15NeoplasmsAnimalsCell DifferentiationMiceReceptors, Antigen, T-CellT-Lymphocytes, CytotoxicInterleukin-15Receptors, Antigen, T-Cell

Identifiers

PMID35444279
PMCPMC9250102
OpenAlexW4224293494

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.