ArticleNature2022
Somatic mosaicism reveals clonal distributions of neocortical development.
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In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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38citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Increased somatic mosaicism in autosomal and X chromosomes for suicide death.Molecular psychiatry · 2025Pooled it
- Origins and timing of somatic variants in the brain.Current opinion in genetics & development · 2026Review
- Somatic mosaicism in the brain: linking development, ageing and neurodegeneration.Nature reviews. Neurology · 2026Review
- SPACE-seq integrates spatial transcriptomics and lineage tracing in native tissues.Cell stem cell · 2026Article
- Article
- Disease insights from brain somatic mosaicism.Experimental & molecular medicine · 2026Review
- Combined somatic mutation and transcriptome analysis reveals region-specific differences in clonal architecture in human cortex.Cell reports · 2025Article
- A personalized multi-platform assessment of somatic mosaicism in the human frontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Brain somatic mutations in Alzheimer's disease: linking genetic mosaicism to neurodegeneration.Molecular neurodegeneration · 2025Review
- Somatic Mosaicism Patterns Define Clinical-Surgical Subtypes of Focal Cortical Dysplasia Through Cell-Type-Specific Expression.medRxiv : the preprint server for health sciences · 2025Article
- The Somatic Mosaicism across Human Tissues Network.Nature · 2025Review
- Human brain ancestral barcodes.eLife · 2025Article
- Cell-type-specific patterns and consequences of somatic mutation in development and aging brain.bioRxiv : the preprint server for biology · 2025Article
- Dipping Into the Phenotypic Implications of Mosaic Variants.Neurology. Genetics · 2025Article
- Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single-cell resolution.Nature methods · 2025Article
- Reconstructing developmental lineages: a retrospective approach using somatic mutations and variant allele frequency.Frontiers in genetics · 2025Review
- Backtracking Cell Phylogenies in the Human Brain with Somatic Mosaic Variants.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Building the brain mosaic: an expanded view.Trends in genetics : TIG · 2024Review
- Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress.Nature communications · 2024Article
- Genome-wide detection of somatic mosaicism at short tandem repeats.Bioinformatics (Oxford, England) · 2024Article
Corrections and comments
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Authors and funding
26 authors at 16 institutions in 3 countries.
Martin W Breuss *Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Xiaoxu Yang *Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0219-0023
Johannes C M Schlachetzki *Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-7801-9743
Danny Antaki *Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Addison J LanaDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Xin XuDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Changuk ChungDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Guoliang ChaiDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Valentina StanleyDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Qiong SongDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Traci F NewmeyerDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
An NguyenDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Sydney O'BrienDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Marten A HoeksemaDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-5981-121X
Beibei CaoDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Alexi NottDepartment of Brain Sciences, Imperial College London, White City Campus, London, UK.
Jennifer McEvoy-VenneriDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Martina P PasillasDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Scott T BartonDivision of Medical Education, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Brett R CopelandDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Shareef NahasRady Children's Institute for Genomic Medicine, San Diego, CA, USA.
Lucitia Van Der KraanRady Children's Institute for Genomic Medicine, San Diego, CA, USA.
Yan DingRady Children's Institute for Genomic Medicine, San Diego, CA, USA.
NIMH Brain Somatic Mosaicism Network
Christopher K GlassDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Joseph G GleesonDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA. jogleeson@health.ucsd.edu.ORCID http://orcid.org/0000-0002-6713-8018
Children’s Institute · USHarvard University · USBoston Children's Hospital · USUniversity of Michigan · USUniversity of California San Diego · USUniversitat Pompeu Fabra · ESYale University · USLieber Institute for Brain Development · USSalk Institute for Biological Studies · USKennedy Krieger Institute · USIcahn School of Medicine at Mount Sinai · USMayo Clinic in Florida · USStanford University · USSage Bionetworks · USUK Dementia Research Institute · GBUniversity of California, Los Angeles · US
Funding
PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3MU of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0MProject II - Modeling meningomyelocele in frog using human alleles and folic acid exposureP01HD104436 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NISWANDER, LEE A. · 2021 to 2025
$7.0MThe Enhancer Code of AD-A Genetic ApproachR01AG056511 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLASS, CHRISTOPHER K, ROSENFELD, MICHAEL G · 2018 to 2022
$5.3MMosaicism in focal cortical dysplasias spectrum seen in neuropsychiatric diseaseU01MH108898 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G · 2015 to 2019
$5.1MMechanisms controlling human microglia gene expressionR01NS096170 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLASS, CHRISTOPHER K · 2016 to 2025
$4.3MMolecular characterization of HemimegalencephalyR01NS083823 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, MATHERN, GARY W. · 2013 to 2017
$3.1MDefining the cell-specific epigenetic landscape leading to altered gene expression signatures in HIV-Associated Neurocognitive DisorderRF1AG061060 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLASS, CHRISTOPHER K · 2018 to 2018
$2.7MOrigins of Brain Somatic Mosaicism in Developmental Brain DiseaseR01MH124890 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G · 2021 to 2025
$1.5MIllumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600kBurden of brain somatic mosaicism in Alzheimer's diseaseR21AG070462 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G · 2020 to 2020
$434kHoward Hughes Medical InstituteMedical Research Council UKNIA NIH HHS R01 AG056511NIA NIH HHS R21 AG070462NIA NIH HHS RF1 AG061060NICHD NIH HHS P01 HD104436NIGMS NIH HHS T32 GM007544NIH HHS S10 OD026929NIMH NIH HHS R01 MH124890NIMH NIH HHS U01 MH108898NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS083823NINDS NIH HHS R01 NS096170
Abstract
The structure of the human neocortex underlies species-specific traits and reflects intricate developmental programs. Here we sought to reconstruct processes that occur during early development by sampling adult human tissues. We analysed neocortical clones in a post-mortem human brain through a comprehensive assessment of brain somatic mosaicism, acting as neutral lineage recorders
Indexed as
Clone CellsMosaicismNeocortexCell LineageCells, CulturedHumansMicroglia
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