ArticleThe ISME journal2022
Coral holobiont cues prime Endozoicomonas for a symbiotic lifestyle.
Article in The ISME journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.
- Systematic review of cnidarian microbiomes reveals insights into the structure, specificity, and fidelity of marine associations.Nature communications · 2023Pooled it
- UniCoracle: automated hierarchical feature selection via bottom-up propagation and top-down skimming using the UniCorP algorithm and the Coracle machine-learning framework.Bioinformatics (Oxford, England) · 2026Article
- Coral-associated microbiome dynamics under thermal and pollution stress.Conservation biology : the journal of the Society for Conservation Biology · 2026Article
- Evaluation of Redox-Mediated Responses of Coral Symbiotic Dinoflagellates to Nano-Selenium.Marine drugs · 2026Article
- Stress-Resistant Symbiodiniaceae and Diverse Bacterial Communities Promote Coral Persistence in Variable, Multi-Stressor Environments.Ecology and evolution · 2026Article
- Manganese supplementation enhances cnidarian-dinoflagellate symbiosis under thermal stress.Communications biology · 2026Article
- Review
- Role of Core Microbiome Shifts in Octocoral Litophyton Under Diurnal Temperature Fluctuations.Microbial ecology · 2026Article
- Nutritional and Microbial Responses of Pocillopora verrucosa to Co-Culture With Chromis viridis Damselfish.Environmental microbiology reports · 2026Article
- Pseudoalteromonas is a symbiont of marine invertebrates that exhibits broad patterns of phylosymbiosis.The ISME journal · 2026Article
- Endozoicomonas acroporae enhances coral thermal resilience through host-microbe coordination.The ISME journal · 2026Article
- Convergent symbioses: morphology, life history, and niche specialization in coral and lichen mutualisms.FEMS microbiology reviews · 2026Review
- Subcuticular symbionts of intertidal brittle stars: diversity, host specificity, and functional potential.ISME communications · 2026Article
- Resolving the evolutionary duality of marine symbionts: redefining the genusISME communications · 2026Article
- Seasonal and spatial dynamics of the microbiome of the polychaete Lanice conchilega in the Wadden Sea.Scientific reports · 2025Article
- Functional stability of Spirochaetota symbionts in the precious octocoral Corallium rubrum under heat stress.Environmental microbiome · 2025Article
- Generating gnotobiotic bivalves: a new method on Manila clam (Microbiology spectrum · 2025Article
- A genomic view of the bacterial family Endozoicomonadaceae in marine symbioses.Communications biology · 2025Review
- Genomic prediction of symbiotic interactions between two Endozoicomonas clades and their coral host, Acropora loripes.Animal microbiome · 2025Article
- Symbiodiniaceae and Bacterial Microbiome Dynamics Differentially Impact the Survival of Dominant Reef-Flat Porites Corals.Environmental microbiology · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
Endozoicomonas are prevalent, abundant bacterial associates of marine animals, including corals. Their role in holobiont health and functioning, however, remains poorly understood. To identify potential interactions within the coral holobiont, we characterized the novel isolate Endozoicomonas marisrubri sp. nov. 6c and assessed its transcriptomic and proteomic response to tissue extracts of its native host, the Red Sea coral Acropora humilis. We show that coral tissue extracts stimulated differential expression of genes putatively involved in symbiosis establishment via the modulation of the host immune response by E. marisrubri 6c, such as genes for flagellar assembly, ankyrins, ephrins, and serpins. Proteome analyses revealed that E. marisrubri 6c upregulated vitamin B1 and B6 biosynthesis and glycolytic processes in response to holobiont cues. Our results suggest that the priming of Endozoicomonas for a symbiotic lifestyle involves the modulation of host immunity and the exchange of essential metabolites with other holobiont members. Consequently, Endozoicomonas may play an important role in holobiont nutrient cycling and may therefore contribute to coral health, acclimatization, and adaptation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.