ArticleCommunications biology2022
Deletion of neural estrogen receptor alpha induces sex differential effects on reproductive behavior in mice.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Estrogen Control of Social Behaviors.Annual review of neuroscience · 2025Review
- Perinatal exposure to lead alters male reproductive behaviour and immunoreactivity of androgen and oestrogen receptors in the brain.International journal of experimental pathology · 2025Article
- Effects of minipuberty disruption on the expression of sexual behavior in female mice.Scientific reports · 2024Article
- Neuroendocrinology of sexual behavior.International journal of impotence research · 2024Review
- Stress during pubertal development affects female sociosexual behavior in mice.Nature communications · 2024Article
- Reproductive function and behaviors: an update on the role of neural estrogen receptors alpha and beta.Frontiers in endocrinology · 2024Review
- The interaction of BDNF with estrogen in the development of hypertension and obesity, particularly during menopause.Frontiers in endocrinology · 2024Review
- Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains.Biology of sex differences · 2023Article
- Behavior, Neural Structure, and Metabolism in Adult Male Mice Exposed to Environmentally Relevant Doses of Di(2-ethylhexyl) Phthalate Alone or in a Phthalate Mixture.Environmental health perspectives · 2023Article
- The role of oestrogen in determining sexual dimorphism in energy balance.The Journal of physiology · 2023Review
- Maternal androgen excess significantly impairs sexual behavior in male and female mouse offspring: Perspective for a biological origin of sexual dysfunction in PCOS.Frontiers in endocrinology · 2023Article
- Deciphering the Roles & Regulation of Estradiol Signaling during Female Mini-Puberty: Insights from Mouse Models.International journal of molecular sciences · 2022Review
- Behavioral Effects of Exposure to Phthalates in Female Rodents: Evidence for Endocrine Disruption?International journal of molecular sciences · 2022Review
- Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estrogen receptor (ER) α is involved in several estrogen-modulated neural and peripheral functions. To determine its role in the expression of female and male reproductive behavior, a mouse line lacking the ERα in the nervous system was generated. Mutant females did not exhibit sexual behavior despite normal olfactory preference, and had a reduced number of progesterone receptor-immunoreactive neurons in the ventromedial hypothalamus. Mutant males displayed a moderately impaired sexual behavior and unaffected fertility, despite evidences of altered organization of sexually dimorphic populations in the preoptic area. In comparison, males deleted for both neural ERα and androgen receptor (AR) displayed greater sexual deficiencies. Thus, these data highlight a predominant role for neural ERα in females and a complementary role with the AR in males in the regulation of sexual behavior, and provide a solid background for future analyses of neuronal versus glial implication of these signaling pathways in both sexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.