Evidence map›Paper›PMID 35444206›Full record

ArticleNature communications2022

RNA polymerase II pausing factor NELF in CD8

Bogang Wu, Xiaowen Zhang, Huai-Chin Chiang, Haihui Pan, Bin Yuan, Payal Mitra, Leilei Qi, Hayk Simonyan, Colin N Young, Eric Yvon and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Myeloid cells meet CD8Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024
    Article
  6. Epigenetic regulation of tumor immunity.The Journal of clinical investigation · 2024
    Review
  7. Decoding Heterogenous Single-cell Perturbation Responses.bioRxiv : the preprint server for biology · 2023
    Article
  8. Article
  9. BRCA1 deficiency in mature CD8Journal for immunotherapy of cancer · 2023
    Article
  10. Strategies to reinvigorate exhausted CD8Frontiers in immunology · 2023
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Bogang Wu *Department of Biochemistry & Molecular Medicine, The George Washington University, Washington, DC, 20037, USA.ORCID http://orcid.org/0000-0003-1654-198X
Xiaowen Zhang *Department of Biochemistry & Molecular Medicine, The George Washington University, Washington, DC, 20037, USA.
Huai-Chin ChiangDepartment of Biochemistry & Molecular Medicine, The George Washington University, Washington, DC, 20037, USA.
Haihui PanDepartment of Biochemistry & Molecular Medicine, The George Washington University, Washington, DC, 20037, USA.
Bin YuanDepartment of Biochemistry & Molecular Medicine, The George Washington University, Washington, DC, 20037, USA.
Payal MitraDepartment of Anatomy & Cell Biology, The George Washington University, Washington, DC, 20037, USA.
Leilei QiDepartment of Anatomy & Cell Biology, The George Washington University, Washington, DC, 20037, USA.
Hayk SimonyanDepartment of Pharmacology & Physiology, The George Washington University, Washington, DC, 20037, USA.
Colin N YoungDepartment of Pharmacology & Physiology, The George Washington University, Washington, DC, 20037, USA.
Eric YvonDepartment of Medicine, The George Washington University Cancer Center School of Medicine & Health Sciences, The George Washington University, Washington, DC, 20037, USA.
Yanfen HuDepartment of Anatomy & Cell Biology, The George Washington University, Washington, DC, 20037, USA.
Nu ZhangDepartment of Microbiology, Immunology & Molecular Genetics, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.ORCID http://orcid.org/0000-0001-9695-210X
Rong LiDepartment of Biochemistry & Molecular Medicine, The George Washington University, Washington, DC, 20037, USA. rli69@gwu.edu.ORCID http://orcid.org/0000-0002-6471-6580
George Washington University · USThe University of Texas Health Science Center at San Antonio · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Brain endoplasmic reticulum stress in non-alcoholic fatty liver diseaseR01DK117007 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI YOUNG, COLIN NEAL · 2018 to 2022
$2.5M
Forebrain-hypothalamic mechanisms in obesity-induced hypertensionR01HL141393 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI YOUNG, COLIN NEAL · 2018 to 2022
$2.4M
Boosting Antitumor Immunity by Blocking Both Tumor and Adipose DDR1R01CA246707 · NCI · GEORGE WASHINGTON UNIVERSITY · PI LI, RONG · 2020 to 2024
$2.3M
Crosstalk between BRCA1 and Transcription in Breast CancerR01CA220578 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LI, RONG · 2017 to 2022
$2.1M
Role of BRCA1 phosphorylation in DNA DSB repair and genome stability maintenanceR01CA212674 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HU, YANFEN, LI, RONG · 2017 to 2022
$1.9M
High Throughput DNA Sequencer: Illumina HiSeq 3000 SequencerS10OD021805 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2016 to 2016
$600k
NCI NIH HHS P30 CA054174NCI NIH HHS R01 CA212674NCI NIH HHS R01 CA220578NCI NIH HHS R01 CA246707NHLBI NIH HHS R01 HL141393NIDDK NIH HHS R01 DK117007NIH HHS S10 OD021805
6 · The paper itself

Abstract

T cell factor 1 (TCF1) is required for memory and stem-like CD8

Indexed as

CD8-Positive T-LymphocytesRNA Polymerase IIAnimalsMicePromoter Regions, GeneticTranscription Factorsnegative elongation factorNELF protein, mouseRNA Polymerase IITranscription Factors

Identifiers

PMID35444206
PMCPMC9021285
OpenAlexW4224286203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.