ArticleNPJ biofilms and microbiomes2022
Early microbial markers of periodontal and cardiometabolic diseases in ORIGINS.
Article in NPJ biofilms and microbiomes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Microbial Markers for Diagnosis and Risk Assessment for Periodontal Diseases: A Systematic Literature Search and Narrative Synthesis.Journal of clinical periodontology · 2025Pooled it
- Precision periodontology in clinical practice: bridging omics and clinical decision-making.Clinical oral investigations · 2026Review
- Periodontal disease and cardiovascular events: mechanisms, biomarkers, and clinical translation.NPJ cardiovascular health · 2026Review
- Salivary microbiota and clinical periodontal measures predicting cardiometabolic disease mortality: A nationwide survey.Journal of periodontology · 2026Article
- Article
- Metagenome-based virome analysis identifies the oral viral signatures for periodontitis.Journal of oral microbiology · 2026Article
- The Periodontal-Cardiovascular Disease Association: Molecular Mechanisms and Clinical Implications.International journal of molecular sciences · 2025Review
- Subgingival Microbiome Profiles in Bulgarian Children Aged 10-14 with Gingival Inflammation and Healthy Periodontium: A Targeted PCR Study.Microorganisms · 2025Article
- Association Between Dietary Patterns and Subgingival Microbiota: Results From the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (ORIGINS).Journal of clinical periodontology · 2025Article
- Quantifying periodontitis-associated oral dysbiosis in tongue and saliva microbiomes-An integrated data analysis.Journal of periodontology · 2025Article
- Association between the severity of gingival inflammation and microbial findings in children.Frontiers in dental medicine · 2025Article
- Salivary microbiome and periodontopathogen/denitrifying bacteria associated with gingivitis and periodontitis in people with type 2-diabetes.F1000Research · 2025Article
- Salivary features of periodontitis and gingivitis in type 2 diabetes mellitus.Scientific reports · 2024Article
- Pooled analysis of oral microbiome profiles defines robust signatures associated with periodontitis.mSystems · 2024Article
- The Effects of Aspirin Intervention on Inflammation-Associated Lingual Bacteria: A Pilot Study from a Randomized Clinical Trial.Microorganisms · 2024Article
- Molecular commensalism: how oral corynebacteria and their extracellular membrane vesicles shape microbiome interactions.Frontiers in oral health · 2024Article
- Comparative characterization of inflammatory profile and oral microbiome according to an inflammation-based risk score in ST-segment elevation myocardial infarction.Frontiers in cellular and infection microbiology · 2023Article
- Unlocking Modifiable Risk Factors for Alzheimer's Disease: Does the Oral Microbiome Hold Some of the Keys?Journal of Alzheimer's disease : JAD · 2023Review
- Associations between Periodontitis, COVID-19, and Cardiometabolic Complications: Molecular Mechanisms and Clinical Evidence.Metabolites · 2022Review
- Salivary Microbiome Profile of Diabetes and Periodontitis in a Chinese Population.Frontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
Periodontitis affects up to 50% of individuals worldwide, and 8.5% are diagnosed with diabetes. The high-comorbidity rate of these diseases may suggest, at least in part, a shared etiology and pathophysiology. Changes in oral microbial communities have been documented in the context of severe periodontitis and diabetes, both independently and together. However, much less is known about the early oral microbial markers of these diseases. We used a subset of the ORIGINS project dataset, which collected detailed periodontal and cardiometabolic information from 787 healthy individuals, to identify early microbial markers of periodontitis and its association with markers of cardiometabolic health. Using state-of-the-art compositional data analysis tools, we identified the log-ratio of Treponema to Corynebacterium bacteria to be a novel Microbial Indicator of Periodontitis (MIP), and found that this MIP correlates with poor periodontal health and cardiometabolic markers early in disease pathogenesis in both subgingival plaque and saliva.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.