Evidence map›Paper›PMID 35443991›Full record

ArticleeNeuro

Conditions for Synaptic Specificity during the Maintenance Phase of Synaptic Plasticity.

Marco A Huertas, Adam J H Newton, Robert A McDougal, Todd Charlton Sacktor, Harel Z Shouval

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Marco A HuertasDepartment of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030.
Adam J H NewtonYale Center for Medical Informatics, New Haven, CT 06520.
Robert A McDougalYale Center for Medical Informatics, New Haven, CT 06520.ORCID https://orcid.org/0000-0001-6394-3127
Todd Charlton SacktorDepartment of Physiology, Pharmacology, Anesthesiology, and Neurology, SUNY Downstate Health Sciences University, Brooklyn, NY 11203.
Harel Z ShouvalDepartment of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030 harel.shouval@uth.tmc.edu.ORCID https://orcid.org/0000-0003-2799-1337
SUNY Downstate Health Sciences University · USRice University · USThe University of Texas at Austin · USYale Cancer Center · US

Funding

Extension of NEURON simulator for simulation of reaction-diffusion in neuronsR01MH086638 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI LYTTON, WILLIAM W, MCDOUGAL, ROBERT A. · 2010 to 2025
$6.0M
PROTEIN KINASE C ISOZYMES IN HIPPOCAMPAL PLASTICITYR01MH053576 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI SACKTOR, TODD C · 2000 to 2014
$4.9M
Reinforcement Based Treatment for Pregnant Drug AbusersR01DA014979 · NIDA · JOHNS HOPKINS UNIVERSITY · PI CHISOLM, MARGARET SMITH · 2002 to 2013
$4.4M
Molecular mechanisms of memory maintenance and dysfunction in neural circuitsR01MH115304 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI FENTON, ANDRE ANTONIO, SACKTOR, TODD C · 2018 to 2022
$4.1M
Regulation and Neural Function of Atypical PKCR37MH057068 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI SACKTOR, TODD C · 2011 to 2020
$4.0M
Minocycline Plus N-Acetylcysteine Improves Brain Structure and Function After Experimental Brain Injury with Clinically Useful Time WindowsR01NS108190 · NINDS · SUNY DOWNSTATE MEDICAL CENTER · PI BERGOLD, PETER J, SACKTOR, TODD C · 2019 to 2023
$2.6M
Neural coordination and discoordination in Fmr1 null miceR01NS105472 · NINDS · NEW YORK UNIVERSITY · PI FENTON, ANDRE ANTONIO · 2017 to 2021
$1.8M
NIDA NIH HHS R01 DA014979NIMH NIH HHS R01 MH053576NIMH NIH HHS R01 MH086638NIMH NIH HHS R01 MH115304NIMH NIH HHS R37 MH057068NINDS NIH HHS R01 NS105472NINDS NIH HHS R01 NS108190
6 · The paper itself

Abstract

Activity-dependent modifications of synaptic efficacies are a cellular substrate of learning and memory. Experimental evidence shows that these modifications are synapse specific and that the long-lasting effects are associated with the sustained increase in concentration of specific proteins like PKM

Indexed as

Long-Term PotentiationNeuronal PlasticityDendritic SpinesDiffusionHippocampusNeuronsSynapsesLTPmaintenanceprotein synthesissynapse specificitysynaptic plasticity

Identifiers

PMID35443991
PMCPMC9087736
OpenAlexW4225778012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.