Evidence map›Paper›PMID 35443985›Full record

ArticleStroke and vascular neurology2022

China Stroke Statistics: an update on the 2019 report from the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations.

Yong-Jun Wang, Zi-Xiao Li, Hong-Qiu Gu, Yi Zhai, Qi Zhou, Yong Jiang, Xing-Quan Zhao, Yi-Long Wang, Xin Yang, Chun-Juan Wang and 12 more

3 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Stroke and vascular neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 250 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
250citing papers in PubMed, 8 pooled it
52.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06817512 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Health Effects of Vitamin K2 Supplementation on Skeletal Muscle and Neurological Function After Ischemic Stroke

TypeinterventionalSponsorHarbin Medical UniversityRan2025 to 2028Enrolled190ConditionsIschemic StrokeArmsVitamin K2, Placebo
NCT07156344 completednot on this map

An Observational Cohort Study on the Identification and Outcome Evaluation of Intracranial Atherosclerotic Plaque Vulnerability

TypeobservationalSponsorXuanwu Hospital, BeijingRan2019 to 2025Enrolled3,849ConditionsAsymptomatic Intracranial Atherosclerotic Stenosis PatientsArmsProgression and Outcome of Intracranial Atherosclerosis
NCT07754942 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Local-to-Systemic Inflammatory Biomarker Gradients and 90-Day Functional Outcomes in Patients With Acute Ischemic Stroke Due to Anterior Circulation Large Vessel Occlusion Undergoing Mechanical Thrombectomy: A Prospective Observational Cohort Study

TypeobservationalSponsorZhongshan Hospital Xiamen UniversityRan2026 to 2029Enrolled50ConditionsAcute Ischemic Stroke, Large Vessel OcclusionArmsProspective Mechanical Thrombectomy Cohort
3 · Its place in the literature

Who cites it

250 citing papers in PubMed, 8 syntheses or guidelines pooled it, 354 citations in OpenAlex.

  1. Measurement properties of Chinese-version assessment tools of health-related quality of life in patients with stroke: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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  9. Smart Healthcare-Enabled Information-Motivation-Behavioral Skills Model for Stroke Multimorbidity Rehabilitation: A Transitional Care Study.Medical science monitor : international medical journal of experimental and clinical research · 2026
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  11. The impact of transcranial direct current stimulation on brain network connectivity and topology in post-stroke cognitive impairment patients: a resting-state fMRI study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  14. Posttreatment Blood Pressure as a Key Predictor in a 5-Year Stroke Prediction Model.Journal of clinical hypertension (Greenwich, Conn.) · 2025
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190 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 2 countries.

Yong-Jun Wang *China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China yongjunwang@ncrcnd.org.cn zhaojz205@163.com Marshal0001@163.com.
Zi-Xiao Li *China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hong-Qiu Gu *China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-1608-1856
Yi Zhai *China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Qi ZhouChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yong JiangChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xing-Quan ZhaoChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-8345-5147
Yi-Long WangChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xin YangChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Chun-Juan WangChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xia MengChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hao LiChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-8591-4105
Li-Ping LiuChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jing JingChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-9822-5758
Jing WuNational Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
An-Ding XuDepartment of Neurology and Stroke Center, The First Affiliated Hospital, Jinan University, Guangzhou, China.ORCID 0000-0003-3154-0985
Qiang DongDepartment of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.ORCID 0000-0002-3874-0130
David WangNeurovascular Division, Department of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
Wen-Zhi WangDepartment of Neuroepidemiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Xu-Dong MaBureau of Medical Administration, National Health Commission of the People's Republic of China, Beijing, China yongjunwang@ncrcnd.org.cn zhaojz205@163.com Marshal0001@163.com.
Ji-Zong ZhaoChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China yongjunwang@ncrcnd.org.cn zhaojz205@163.com Marshal0001@163.com.
China Stroke Statistics Writing Committee
Capital Medical University · CNBarrow Neurological Institute · USFudan University · CNNational Institute of Hospital Administration · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

China faces the greatest challenge from stroke in the world. According to results from the Global Burden of Disease Study 2019, there were 3.94 million new stroke cases, 28.76 million prevalent cases and 2.19 million deaths due to stroke in China in 2019. Furthermore, stroke is also the leading cause of disability-adjusted life-year (DALY) in China, the number of DALYs reached 45.9 million in 2019. Several recent large-scale epidemiological surveys have updated the data on pre-existing conditions contributed to stroke. The age-adjusted prevalence of overweight among Chinese adults aged 18-69 years was 34.4%, and the prevalence of obesity was 16.8% in 2018. 50.9% of Chinese adults ≥18 years of age without history of hypertension had prehypertension in 2018. The weighted prevalence of hypertension in adults was 27.5% in 2018. The weighted prevalence of total diabetes and pre-diabetes diagnosed by the American Diabetes Association criteria were 12.8% and 35.2%, respectively, among Chinese adults ≥18 years of age in 2017. The weighted atrial fibrillation prevalence was 1.8% among Chinese adults ≥45 years of age and equates to being present in an estimated 7.9 million people in China. Data from 1672 tertiary public hospitals in the Hospital Quality Monitoring System (HQMS) showed that 3 411 168 stroke cases were admitted during 2019. Of those, 2 818 875 (82.6%) were ischaemic strokes (ISs), 485 474 (14.2%) were intracerebral haemorrhages (ICHs), 106 819 (3.1%) were subarachnoid haemorrhages (SAHs). The average age was 66 years old, and 59.6% were male. A total of 1379 (<0.1%), 2604 (0.5%), 1250 (1.2%) paediatric strokes (age <18 years) were identified among IS, ICH and SAH, respectively. Over one-third (1 231 519 (36.1%)) of the stroke cases were covered by urban resident basic medical insurance, followed by urban employee basic medical insurance (891 103 (26.1%)) and new rural cooperative medical schema (543 108 (15.9%)). The leading risk factor was hypertension (57.3% for IS, 69.9% for ICH and 44.1% for SAH), and the leading comorbidity was pneumonia or pulmonary infection (10.4% for IS, 34.6% for ICH and 29.7% for SAH). In-hospital death/discharge against medical advice rate was 8.5%, ranging from 6.0% for IS to 20.6% for SAH. The median and IQR of length of stay was 9.0 (6.0-13.0) days, ranging from 10.0 (7.0-13.0) in IS to 14.0 (8.0-22.0) in ICH. Similar data from 2847 secondary public hospitals or private hospitals in the HQMS were also reported. Data from HQMS showed that higher proportions of interprovincial admission to other provinces were seen in Inner Mongolia, Anhui, Tibet and Beijing. Higher proportions of interprovincial admission from other provinces were seen in Beijng, Tianjin, Shanghai and Ningxia. Data from 323 601 strokes from 1337 hospitals in the Chinese Stroke Center Alliance during 2019 demonstrated that the composite scores of guideline-recommended key performance indicators for patients with IS, ICH and SAH were 0.78±0.20, 0.69±0.27 and 0.60±0.31, respectively.

Indexed as

HypertensionNoncommunicable DiseasesStrokeAdolescentAdultAgedCenters for Disease Control and Prevention, U.S.ChildChinaFemaleHospital MortalityHumansMaleMiddle AgedRisk FactorsUnited Statesstroke

Identifiers

PMID35443985
PMCPMC9614174
OpenAlexW4224249510

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.